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The use of calcium phosphate-based biomaterials in implant dentistry

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Abstract

Since calcium phosphates (CaPs) were first proposed, a wide variety of formulations have been developed and continuously optimized, some of which (e.g. calcium phosphate cements, CPCs) have been successfully commercialized for clinical applications. These CaP-based biomaterials have been shown to be very attractive bone substitutes and efficient drug delivery vehicles across diverse biomedical applications. In this article, CaP biomaterials, principally CPCs, are addressed as alternatives/complements to autogenous bone for grafting in implant dentistry and as coating materials for enhancing the osteoinductivity of titanium implants, highlighting their performance benefits simultaneously as carriers for growth factors and as scaffolds for cell proliferation, differentiation and penetration. Different strategies for employing CaP biomaterials in dental implantology aim to ultimately reach the same goal, namely to enhance the osseointegration process for dental implants in the context of immediate loading and to augment the formation of surrounding bone to guarantee long-term success.

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Abbreviations

BMP(s):

Bone morphogenetic protein(s)

CaP(s):

Calcium phosphate(s)

CPC(s):

Calcium phosphate cement(s)

DPBS:

Dulbecco’s phosphate buffered saline

FGF:

Fibroblast growth factor

HA:

Hydroxyapatite

PLA:

Polylactic acid

PRP:

Platelet-rich plasma

TCP:

Tricalcium phosphate

TGF(s):

Transforming growth factor(s)

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Acknowledgments

We apologize to our colleagues whose work could not be cited due to space constraints. Funding from the National Natural Science Foundation of China (81071253) for some of the work mentioned in the article is gratefully appreciated. We wish to thank all contributors for the substantial information that was compiled in previously published reviews that were cited in this manuscript. Their information was immensely helpful for preparing this manuscript.

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The authors declare that there is no conflict of interest

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Authors and Affiliations

  1. Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, 145th West Chang-le Road, **’an, 710032, Shaanxi, People’s Republic of China

    Cheng **e & Yi-Min Zhao

  2. Department of Periodontology & Oral Medicine, School of Stomatology, Fourth Military Medical University, 145th West Chang-le Road, **’an, 710032, Shaanxi, People’s Republic of China

    Hong Lu & Fa-Ming Chen

  3. Department of Neurology, General Hospital of Shenyang Military Command, 83rd Wen-hua Road, Shenyang, 110016, Liaoning, People’s Republic of China

    Wei Li

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  1. Cheng **e
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Correspondence to Fa-Ming Chen or Yi-Min Zhao.

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C. **e, H. Lu and W. Li contributed equally to this manuscript.

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**e, C., Lu, H., Li, W. et al. The use of calcium phosphate-based biomaterials in implant dentistry. J Mater Sci: Mater Med 23, 853–862 (2012). https://doi.org/10.1007/s10856-011-4535-9

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