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  1. No Access

    Article

    Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease

    Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent in Alzheimer disease (AD with psychosis, AD + P). AD + P affects ~50% of individuals with AD, identifies a subgroup wi...

    Mary Ann A. DeMichele-Sweet, Lambertus Klei, Byron Creese… in Molecular Psychiatry (2021)

  2. Article

    Open Access

    A polygenic predictor of treatment-resistant depression using whole exome sequencing and genome-wide genoty**

    Treatment-resistant depression (TRD) occurs in ~30% of patients with major depressive disorder (MDD) but the genetics of TRD was previously poorly investigated. Whole exome sequencing and genome-wide genotypin...

    Chiara Fabbri, Siegfried Kasper, Alexander Kautzky… in Translational Psychiatry (2020)

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  3. No Access

    Article

    Neuroplasticity and second messenger pathways in antidepressant efficacy: pharmacogenetic results from a prospective trial investigating treatment resistance

    Genes belonging to neuroplasticity, monoamine, circadian rhythm, and transcription factor pathways were investigated as modulators of antidepressant efficacy. The present study aimed (1) to replicate previous ...

    Chiara Fabbri, Concetta Crisafulli… in European Archives of Psychiatry and Clinic… (2017)

  4. No Access

    Article

    Clinical and genetic factors associated with suicide in mood disorder patients

    Suicidality is a continuum ranging from ideation to attempted and completed suicide, with a complex etiology involving both genetic heritability and environmental factors. The majority of suicide events occur ...

    Niki Antypa, Daniel Souery, Mario Tomasini… in European Archives of Psychiatry and Clinic… (2016)

  5. No Access

    Article

    Genetics of psychotropic medication induced side effects in two independent samples of bipolar patients

    The treatment of bipolar disorder (BD) usually requires combination therapies, with the critical issue of the emergence of adverse drug reactions (ADRs) and the possibility of low treatment adherence. Genetic ...

    Chiara Fabbri, Daniel Souery, Raffaella Calati… in Journal of Neural Transmission (2015)

  6. No Access

    Article

    Association between Sirtuin 2 gene rs10410544 polymorphism and depression in Alzheimer’s disease in two independent European samples

    Among the several genes associated with late-onset Alzheimer’s disease (LOAD), recently, Sirtuin genes have roused a growing interest because of their involvement in metabolic homeostasis and in brain aging. P...

    Stefano Porcelli, Raffaele Salfi, Antonis Politis… in Journal of Neural Transmission (2013)