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Article
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has t...
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Article
Open AccessEfficacy of the additional use of subgingival air-polishing with erythritol powder in the treatment of periodontitis patients: a randomized controlled clinical trial. Part II: effect on sub-gingival microbiome
To date, scarce evidence exists around the application of subgingival air-polishing during treatment of severe periodontitis. The aim of this study was to evaluate the effect on the health-related and periodon...
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Article
Gambling Disorder in an Italian Population: Risk of Suicide Attempts and Associated Demographic-Clinical Factors using Electronic Health Records
To identify the demographic and clinical characteristics associated with access to Emergency Departments for Suicide Attempt in a cohort of patients with Gambling disorders. We used electronic health records o...
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Article
Open AccessThe sociodemographic and clinical profile of patients with major depressive disorder receiving SSRIs as first-line antidepressant treatment in European countries
Due to favorable antidepressant (AD) efficacy and tolerability, selective-serotonin reuptake inhibitors (SSRIs) are consistently recommended as substances of first choice for the treatment of major depressive ...
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Reference Work Entry In depth
Antidepressants: Indications, Contraindications, Interactions, and Side Effects
Antidepressants are among the most largely prescribed medications worldwide. They are the mainstay of depression treatment but are used for other conditions too. As of today, over 40 medications are available....
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Article
Open AccessVitamin D and the risk of treatment-resistant and atypical depression: A Mendelian randomization study
Observational evidence has implicated vitamin D levels as a risk factor in major depressive disorder (MDD). Confounding or reverse causation may be driving these observed associations, with studies using genet...
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Article
Open AccessTranscriptome-wide association study of treatment-resistant depression and depression subtypes for drug repurposing
Major depressive disorder (MDD) is the single largest contributor to global disability and up to 20–30% of patients do not respond to at least two antidepressants (treatment-resistant depression, TRD). This st...
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Article
Open AccessGenetic underpinnings of sociability in the general population
Levels of sociability are continuously distributed in the general population, and decreased sociability represents an early manifestation of several brain disorders. Here, we investigated the genetic underpinn...
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Article
Open AccessGenetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts
Treatment-resistant depression (TRD) is a major contributor to the disability caused by major depressive disorder (MDD). Primary care electronic health records provide an easily accessible approach to investig...
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Article
Efficacy of the additional use of subgingival air polishing with erythritol powder in the treatment of periodontitis patients: a randomized controlled clinical trial
To date, scarce evidence exists around the application of subgingival air polishing during treatment of severe periodontitis. The aim of this study was to evaluate the benefits of subgingival air polishing dur...
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Article
Investigating an in silico approach for prioritizing antidepressant drug prescription based on drug-induced expression profiles and predicted gene expression
In clinical practice, an antidepressant prescription is a trial and error approach, which is time consuming and discomforting for patients. This study investigated an in silico approach for ranking antidepress...
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Chapter
The Role of Genetics in Bipolar Disorder
Bipolar disorder (BP) is a highly heritable disease, with heritability estimated between 60 and 85% by twin studies. The underlying genetic architecture was poorly understood for years since the available tech...
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Article
Reduced plasma Fetuin-A is a promising biomarker of depression in the elderly
Depression affects 7% of the elderly population, and it often remains misdiagnosed or untreated. Peripheral biomarkers might aid clinicians by allowing more accurate and well-timed recognition of the disease. ...
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Article
Open AccessDefining the oral microbiome by whole-genome sequencing and resistome analysis: the complexity of the healthy picture
The microbiome of the oral cavity is the second-largest and diverse microbiota after the gut, harboring over 700 species of bacteria and including also fungi, viruses, and protozoa. With its diverse niches, th...
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Article
Open AccessGenome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP
Antidepressants demonstrate modest response rates in the treatment of major depressive disorder (MDD). Despite previous genome-wide association studies (GWAS) of antidepressant treatment response, the underlyi...
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Article
Open AccessA polygenic predictor of treatment-resistant depression using whole exome sequencing and genome-wide genoty**
Treatment-resistant depression (TRD) occurs in ~30% of patients with major depressive disorder (MDD) but the genetics of TRD was previously poorly investigated. Whole exome sequencing and genome-wide genotypin...
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Living Reference Work Entry In depth
Antidepressants: Indications, Contraindications, Interactions, and Side Effects
Antidepressants are among the most largely prescribed medications worldwide. They are the mainstay of depression treatment but are used for other conditions too. As of today, over 40 medications are available....
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Article
Open AccessGenes associated with anhedonia: a new analysis in a large clinical trial (GENDEP)
A key feature of major depressive disorder (MDD) is anhedonia, which is a predictor of response to antidepressant treatment. In order to shed light on its genetic underpinnings, we conducted a genome-wide asso...
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Chapter
Highlights on Pharmacogenetics and Pharmacogenomics in Depression
This chapter summarizes the current knowledge about the pharmacogenetics and pharmacogenomics of antidepressant drugs in major depressive disorder (MDD). Pharmacogenetics is referred to results of candidate ge...
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Article
Neuroplasticity and second messenger pathways in antidepressant efficacy: pharmacogenetic results from a prospective trial investigating treatment resistance
Genes belonging to neuroplasticity, monoamine, circadian rhythm, and transcription factor pathways were investigated as modulators of antidepressant efficacy. The present study aimed (1) to replicate previous ...
