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Open AccessThe sociodemographic and clinical profile of patients with major depressive disorder receiving SSRIs as first-line antidepressant treatment in European countries
Due to favorable antidepressant (AD) efficacy and tolerability, selective-serotonin reuptake inhibitors (SSRIs) are consistently recommended as substances of first choice for the treatment of major depressive ...
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Open AccessCorrection: Methodology for clinical genoty** of CYP2D6 and CYP2C19
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Open AccessMethodology for clinical genoty** of CYP2D6 and CYP2C19
Many antidepressants, atomoxetine, and several antipsychotics are metabolized by the cytochrome P450 enzymes CYP2D6 and CYP2C19, and guidelines for prescribers based on genetic variants exist. Although some la...
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Article
Open AccessA polygenic predictor of treatment-resistant depression using whole exome sequencing and genome-wide genoty**
Treatment-resistant depression (TRD) occurs in ~30% of patients with major depressive disorder (MDD) but the genetics of TRD was previously poorly investigated. Whole exome sequencing and genome-wide genotypin...
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Article
Open AccessGenes associated with anhedonia: a new analysis in a large clinical trial (GENDEP)
A key feature of major depressive disorder (MDD) is anhedonia, which is a predictor of response to antidepressant treatment. In order to shed light on its genetic underpinnings, we conducted a genome-wide asso...
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Open AccessAntidepressant drug-specific prediction of depression treatment outcomes from genetic and clinical variables
Individuals with depression differ substantially in their response to treatment with antidepressants. Specific predictors explain only a small proportion of these differences. To meaningfully predict who will ...
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Article
Neuroplasticity and second messenger pathways in antidepressant efficacy: pharmacogenetic results from a prospective trial investigating treatment resistance
Genes belonging to neuroplasticity, monoamine, circadian rhythm, and transcription factor pathways were investigated as modulators of antidepressant efficacy. The present study aimed (1) to replicate previous ...
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Clinical and genetic factors associated with suicide in mood disorder patients
Suicidality is a continuum ranging from ideation to attempted and completed suicide, with a complex etiology involving both genetic heritability and environmental factors. The majority of suicide events occur ...
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Open AccessExploring the role of drug-metabolising enzymes in antidepressant side effects
Cytochrome P450 enzymes are important in the metabolism of antidepressants. The highly polymorphic nature of these enzymes has been linked to variability in antidepressant metabolism rates, leading to hope reg...
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Genetics of psychotropic medication induced side effects in two independent samples of bipolar patients
The treatment of bipolar disorder (BD) usually requires combination therapies, with the critical issue of the emergence of adverse drug reactions (ADRs) and the possibility of low treatment adherence. Genetic ...
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Article
Erratum to: Influence of family history of major depression, bipolar disorder, and suicide on clinical features in patients with major depression and bipolar disorder
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Article
The impact of Cytochrome P450 CYP1A2, CYP2C9, CYP2C19 and CYP2D6 genes on suicide attempt and suicide risk—a European multicentre study on treatment-resistant major depressive disorder
Recently published data have reported associations between cytochrome P450 metabolizer status and suicidality. The aim of our study was to investigate the role of genetic polymorphisms of the cytochrome P450 g...
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Influence of family history of major depression, bipolar disorder, and suicide on clinical features in patients with major depression and bipolar disorder
The extent to which a family history of mood disorders and suicide could impact on clinical features of patients suffering from major depression (MD) and bipolar disorder (BD) has received relatively little at...
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Genetic Predictors of Increase in Suicidal Ideation During Antidepressant Treatment in the GENDEP Project
The aim of this study was to investigate genetic predictors of an increase in suicidal ideation during treatment with a selective serotonin reuptake inhibitor or a tricyclic antidepressant. A total of 796 adul...
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Open AccessSuicidal ideation during treatment of depression with escitalopram and nortriptyline in Genome-Based Therapeutic Drugs for Depression (GENDEP): a clinical trial
Suicidal thoughts and behaviours during antidepressant treatment, especially during the first weeks of treatment, have prompted warnings by regulatory bodies. The aim of the present study is to investigate the...
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Genetic predictors of response to antidepressants in the GENDEP project
The objective of the Genome-based Therapeutic Drugs for Depression study is to investigate the function of variations in genes encoding key proteins in serotonin, norepinephrine, neurotrophic and glucocorticoi...
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Glucocorticoid Receptor Gene-Based SNP Analysis in Patients with Recurrent Major Depression
Dysregulation of the hypothalamic-pituitary-adrenal axis, one of the stress-response systems, is one of the key neurobiological features of major depression (MDD). Data supporting the notion that glucocorticoi...
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Pharmacogenetics of bipolar disorders
