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Open AccessProof-of-concept recall-by-genotype study of extremely low and high Alzheimer’s polygenic risk reveals autobiographical deficits and cingulate cortex correlates
Genome-wide association studies demonstrate that Alzheimer’s disease (AD) has a highly polygenic architecture, where thousands of independent genetic variants explain risk with high classification accuracy. Th...
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Article
Open AccessMicroglial activation, tau and amyloid deposition in TREM2 p.R47H carriers and mild cognitive impairment patients: a multi-modal/multi-tracer PET/MRI imaging study with influenza vaccine immune challenge
Microglia are increasingly understood to play an important role in the pathogenesis of Alzheimer’s disease. The rs75932628 (p.R47H) TREM2 variant is a well-established risk factor for Alzheimer’s disease. TREM2 i...
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Article
Open AccessSelf-harm and Suicidality Experiences of Middle-Age and Older Adults With vs. Without High Autistic Traits
Suicide has been identified as a leading cause of premature death in autistic populations. Elevated autistic traits have also been associated with higher rates of self-harm, suicidal ideation, and suicidal sel...
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Article
Open AccessOptimizing detection of Alzheimer’s disease in mild cognitive impairment: a 4-year biomarker study of mild behavioral impairment in ADNI and MEMENTO
Disease-modifying drug use necessitates better Alzheimer disease (AD) detection. Mild cognitive impairment (MCI) leverages cognitive decline to identify the risk group; similarly, mild behavioral impairment (M...
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Article
A longitudinal study of late-life psychosis and incident dementia and the potential effects of race and cognition
Later-life psychotic symptoms are meaningful and are associated with adverse outcomes. Psychosis is an important domain in mild behavioural impairment (MBI), a syndrome that incorporates later-life emergent an...
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Implications of Adverse Outcomes Associated with Antipsychotics in Older Patients with Dementia: A 2011–2022 Update
Neuropsychiatric symptoms affect most patients with dementia over the course of the disease. They include a wide variety of symptoms from apathy and depression to psychosis, irritability, impulsivity and agita...
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Article
Open AccessHealthcare utilisation, physical activity and mental health during COVID-19 lockdown: an interrupted time-series analysis of older adults in England
COVID-19 measures which reduce interpersonal contact may be effective in containing the transmission, but their impacts on peoples’ well-being and daily lives overtime remain unclear. Older adults are more vul...
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Article
Open AccessMachine learning-based prediction of cognitive outcomes in de novo Parkinson’s disease
Cognitive impairment is a debilitating symptom in Parkinson’s disease (PD). We aimed to establish an accurate multivariate machine learning (ML) model to predict cognitive outcome in newly diagnosed PD cases f...
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Article
Neuropsychiatric symptoms in AD: the search for mechanisms
New work building on the results of genome-wide association studies in Alzheimer disease has identified molecular mechanisms that are shared with some psychiatric disorders. The study leveraged ‘omics data and...
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Article
Psychosis in Alzheimer disease — mechanisms, genetics and therapeutic opportunities
Psychosis is a common and distressing symptom in people with Alzheimer disease, and few safe and effective treatments are available. However, new approaches to symptom assessment and treatment are beginning to...
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Article
Open AccessMild behavioral impairment: measurement and clinical correlates of a novel marker of preclinical Alzheimer’s disease
Late-life onset neuropsychiatric symptoms are established risk factors for dementia. The mild behavioral impairment (MBI) diagnostic framework was designed to standardize assessment to determine dementia risk ...
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Article
Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease
Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent in Alzheimer disease (AD with psychosis, AD + P). AD + P affects ~50% of individuals with AD, identifies a subgroup wi...
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Open AccessPsychosis in Alzheimer’s Disease
To review the incidence, treatment and genetics of psychosis in people with mild cognitive impairment (MCI) and Alzheimer’s disease (AD).
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Open AccessCost-Effectiveness of Dementia Care Map** in Care-Home Settings: Evaluation of a Randomised Controlled Trial
Behaviours such as agitation impact on the quality of life of care-home residents with dementia and increase healthcare use. Interventions to prevent these behaviours have little evidence supporting their effe...
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Open AccessExamining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer’s disease
Psychosis (delusions or hallucinations) in Alzheimer’s disease (AD + P) occurs in up to 50% of individuals and is associated with significantly worse clinical outcomes. Atypical antipsychotics, first developed...
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Article
Cognitive decline in Parkinson disease
The full spectrum of cognitive impairment, from subjective cognitive decline to dementia, has been observed in Parkinson disease (PD)
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The psychosis spectrum in Parkinson disease
Parkinson disease (PD) psychosis refers to a spectrum of illusions, hallucinations and delusions that occur throughout the disease course
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Article
Open AccessEvaluating the effectiveness and cost-effectiveness of Dementia Care Map**™ to enable person-centred care for people with dementia and their carers (DCM-EPIC) in care homes: study protocol for a randomised controlled trial
Up to 90 % of people living with dementia in care homes experience one or more behaviours that staff may describe as challenging to support (BSC). Of these agitation is the most common and difficult to manage....
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Article
Complexities of trial recruitment in the care home setting: an illustration via the DCM™epic (dementia care map**™: to enable person-centred care in care homes) trial
