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Article
Childhood cancer survivor care: development of the Passport for Care
Numerous calls for improvement in the quality of follow-up care provided to cancer survivors, particularly survivors of childhood cancer have been issued by key health organizations in the USA; the Passport fo...
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Article
Methotrexate distribution within the subarachnoid space after intraventricular and intravenous administration
Purpose: Intrathecal methotrexate achieves high concentrations in cerebrospinal fluid (CSF), but drug distribution throughout the subarachnoid space after an intralumbar dose is limited. The objective of this st...
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Article
New cytotoxic drugs for intrathecal administration
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Article
Pharmacologic strategies for the treatment of meningeal malignancy
There have been significant strides in the treatment and prevention of meningeal cancer, particularly meningeal leukemia, during the past thirty years. These advantages are a direct result of innovative therap...
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Article
Intrathecal administration of topotecan in nonhuman primates
The cerebrospinal fluid (CSF) pharmacokinetics of topotecan were studied in a nonhuman primate model following intraventricular administration of 0.1 mg. Lactone and total drug concentrations were measured usi...
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Article
Pharmacokinetics, cerebrospinal fluid penetration, and metabolism of piroxantrone in the Rhesus monkey
Piroxantrone is an anthrapyrazole derivative with broad anti-tumor activityin vitro and less cardiac toxicity than the anthracyclines. The metabolic pathways and central nervous system penetration of piroxantrone...
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Article
Pharmacokinetics of PEG-l-asparaginase and plasma and cerebrospinal fluidl-asparagine concentrations in the rhesus monkey
The pharmacokinetics of the polyethylene glycol-conjugated form of the enzymel-asparaginase and the depletion ofl-asparagine from the plasma and cerebrospinal fluid (CSF) following an i.m. dose of 2500 IU/m2 PEG-
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Article
Cerebrospinal fluid pharmacokinetics and toxicology of intraventricular and intrathecal arabinosyl-5-azacytosine (fazarabine, NSC 281272) in the nonhuman primate
Arabinosyl-5-azacytosine (AAC), a new nucleoside antimetabolite, is broadly active in preclinical tumor screening evaluations. To assess the potential for intrathecal use of this drug, we studied the toxicity ...
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Article
Intrathecal 5-fluorouracil in the rhesus monkey
Because meningeal spread of both leukemia and solid tumors remains a difficult therapeutic problem, there is a compelling need to develop new agents for intrathecal administration. 5-Fluorouracil (5FU), an act...
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Article
A phase II trial of continuous-infusion 6-mercaptopurine for childhood leukemia
A phase II pediatric trial of a continuous intravenous infusion of 6-mercaptopurine (6MP) in patients with refractory leukemia was performed. The dosing schedule, 50 mg m−2 h−1 for 48 h, was based on the results ...
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Article
A phase II trial of continuous-infusion 6-mercaptopurine for childhood solid tumors
A phase II pediatric trial of a continuous intravenous infusion of 6-mercaptopurine (6-MP) in patients with refractory solid tumors or lymphoma was performed. The dosing schedule of 50 mg/m2 per hour for 48 h was...
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Article
Phase II trial of sequential methotrexate and 5-fluorouracil with leucovorin in children with sarcomas
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Article
An immunotoxin for the treatment of T-acute lymphoblastic leukemic meningitis: studies in rhesus monkeys
Monoclonal antibody WT1 (anti-CD7), conjugated to ricin A chain, was administered intrathecally to rhesus monkeys to test its suitability for use in the therapy of leukemic meningitis. The WT1-SMPT-dgRTA conju...
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Chapter
New methods of administering old drugs: IV infusion of mercaptopurine
In order to maximize an anti-neoplastic agent’s activity it is essential to consider the drug’s pharmacokinetics. The importance of route and schedule of administration has been well exemplified by the experie...
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Chapter
Pharmacologic approaches to the treatment of central nervous system malignancy
The identification of effective chemotherapy for the treatment of central nervous system (CNS) malignancy poses a major challenge to the oncologist. Although anti-neoplastic chemotherapy has become a mainstay ...
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Chapter
Monocyte-Mediated Antibody-Dependent Cellular Cytotoxicity
During the past decade there has been increasing interest in the role of the mononuclear phagocyte in the immune response. It is now appreciated that these cells subserve a variety of important immunologic fun...
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Article
Pharmacokinetic study of cerebrospinal fluid penetration of cis-diamminedichloroplatinum (II)
The ability of cis-DDP and several analogs to enter the CSF was investigated in rhesus monkeys that had subcutaneoulsy implanted Ommaya reservoirs connected to catheters in each monkey's fourth ventricle. Plas...
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Article
IMMUNODEFICIENCY IN LYMPHOHISTIOCYTOSIS: DEFECTIVE CELLULAR IMMUNITY IN ASSOCIATION WITH HYPERLIPIDEMIA
Lymphohistiocytosis (LH) is a familial syndrome characterized by abnormal accumulation of non-malignant histiocytes in lymph nodes, liver, and spleen, erythrophagocytosis, hepatoaplenomegaly, recurrent fever, ...
