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Chapter
Late Effects in Langerhans Cell Histiocytosis of Young Cancer Patients
Langerhans cell histiocytosis (LCH) is a rare disease with a wide range of clinical presentations and variable outcome. The prognosis of this potentially fatal disease has dramatically improved over the last y...
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Reference Work Entry In depth
Gangliosides
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Living Reference Work Entry In depth
Gangliosides
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Article
Tumor gangliosides accelerate murine tumor angiogenesis
Tumor cells shed gangliosides and populate their microenvironment with these biologically active membrane glycosphingolipids. In vitro, ganglioside enrichment amplifies receptor tyrosine kinase signaling and a...
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Article
Induction of GM1a/GD1b synthase triggers complex ganglioside expression and alters neuroblastoma cell behavior; a new tumor cell model of ganglioside function
Neuroblastoma is the most common extracranial solid tumor in children and tumor ganglioside composition has been linked to its biological and clinical behavior. We recently found that high expression of comple...
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Reference Work Entry In depth
Gangliosides
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Reference Work Entry In depth
Gangliosides
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Article
Structural characterization andin vivo immunosuppressive activity of neuroblastoma GD2
Shedding of neuroblastoma gangliosides is positively correlated with tumour progression in patients with neuroblastoma. In assessing the biological activity of these ganglioside molecules, we recently found th...
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Chapter
Biological Significance of Tumor Gangliosides: Shedding, Transfer, and Immunosuppression
Tumor formation is a complex, multiple-step process influenced by many factors. Local interactions between the tumor cell and the host are critical to tumor formation, and it is becoming recognized that the re...
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Article
VP-16 and the treatment of histiocytosis
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Article
Hepatic Ganglioside Abnormalities in a Patient with Familial Erythrophagocytic Lymphohistiocytosis
Summary: Familial erythrophagocytic lymphohistiocytosis (FEL) is an autosomal recessive disease of unknown pathogenesis. Because of evidence of increased circulating and hepatic lipids in FEL, we performed a c...
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Article
Plasma inhibition of lymphocyte proliferation in nephrotic syndrome: Correlation with hyperlipidemia
Plasma-mediated inhibition of normal lymphoproliferation is an unexplained immunologic abnormality frequently observed in nephrotic syndrome. Since hyperlipidemia, also common in nephrotic syndrome, has been l...
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Chapter
Influence of Monovalent Cation Concentrations on Monocyte-Mediated ADCC
Studies of effector cell biochemical processes associated with cell-mediated cytolysis have been undertaken by numerous laboratories to define the conditions required for the expression of cytolytic activity, ...
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Article
941 PLASMA INHIBITION OF LYMPHOCYTE BLASTOGENESIS IN NEPHROTIC SYNDROME: CORRELATION WITH HYPERLIPIDEMIA
The plasma of patients with Nephrotic Syndrome suppresses in vitro lymphocyte blastogenesis, but the mechanism of this effect has not been defined. The frequent association of Nephrotic Syndrome with hypertriglyc...
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Article
IMMUNODEFICIENCY IN LYMPHOHISTIOCYTOSIS: DEFECTIVE CELLULAR IMMUNITY IN ASSOCIATION WITH HYPERLIPIDEMIA
Lymphohistiocytosis (LH) is a familial syndrome characterized by abnormal accumulation of non-malignant histiocytes in lymph nodes, liver, and spleen, erythrophagocytosis, hepatoaplenomegaly, recurrent fever, ...
