Log in

Phase II trial of sequential methotrexate and 5-fluorouracil with leucovorin in children with sarcomas

  • Preclinical Studies
  • Brief Report
  • Published:
Investigational New Drugs Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Canada)

Instant access to the full article PDF.

References

  1. Benz C, Schoenberg M, Choti M, Cadman E: Schedule-dependent cytotoxicity of methotrexate and 5-fluorouracil in human colon and breast tumor cell lines. J Clin Invest 66:1162–1165, 1980

    Google Scholar 

  2. Ringborg U, Ewert G, Kinnman J, Lundquist P-G, Strander H: Methotrexate and 5-fluorouracil in head and neck cancer. Semin Oncol 10 (Suppl 2):20–22, 1983

    Google Scholar 

  3. Ajani JA, Kanojia MD, Bedikian AY, Korinek JK, Stein SH, Espinoza EG, Bodey GP: Sequential methotrexate and 5-fluorouracil in the primary treatment of metastatic colorectal carcinoma. Am J Clin Oncol 8:69–71, 1985

    Google Scholar 

  4. Tisman G, Wu SJG: Effectiveness of intermediate-dose methotrexate and high-dose 5-fluorouracil as a sequential combination chemotherapy in refractory breast cancer and as primary therapy in metastatic adenocarcinoma of the colon. Cancer Treat Rep 64:829–835, 1980

    Google Scholar 

  5. Krivit W, Bentley HP: Use of 5-fluorouracil in the management of advanced malignancies in childhoos. Am J Dis Child 100:217–227, 1960

    Google Scholar 

  6. Bode U: Methotrexate as relapse therapy for rhabdomyosarcoma. Am J Pediatr Hematol Oncol 8:70–72, 1986

    Google Scholar 

  7. Benz C, Degregorio M, Saks S, Sambol N, Holleran W, Ignoffo R, Lewis B, Cadman E: Sequential infusions of methotrexate and 5-fluorouracil in advanced cancer: pharmacology, toxicity, and response. Cancer Res 45:3354–3358, 1985

    Google Scholar 

  8. Falk LC, Clark DR, Kalman SM, Long TF: Enzymatic assay for methotrexate in serum and cerebrospinal fluid. Clin Chem 22:785–788, 1976

    Google Scholar 

  9. Murphy RF, Balis FM, Poplack DG: The stability of 5-fluorouracil in plasma and whole blood. Clin Chem 33:2299–2300, 1987

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Balis, F.M., Gillespie, A., Belasco, J. et al. Phase II trial of sequential methotrexate and 5-fluorouracil with leucovorin in children with sarcomas. Invest New Drugs 8, 181–182 (1990). https://doi.org/10.1007/BF00177254

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00177254

Key words

Navigation