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Article
A phase II trial of continuous-infusion 6-mercaptopurine for childhood leukemia
A phase II pediatric trial of a continuous intravenous infusion of 6-mercaptopurine (6MP) in patients with refractory leukemia was performed. The dosing schedule, 50 mg m−2 h−1 for 48 h, was based on the results ...
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Article
A phase II trial of continuous-infusion 6-mercaptopurine for childhood solid tumors
A phase II pediatric trial of a continuous intravenous infusion of 6-mercaptopurine (6-MP) in patients with refractory solid tumors or lymphoma was performed. The dosing schedule of 50 mg/m2 per hour for 48 h was...
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Article
Effects of folate in culture medium on common fragile sites in lymphocyte chromosomes from normal and leukemic children
The expression of common fragile sites at 69 bands was evaluated in 20 normal children and in 15 children with newly diagnosed acute leukemia using medium with folate (FA+) and without folate (FA-). As expected, ...
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Article
Toxicity evaluation of dihydroxyanthracenedione (DHAD) in combination with cytosine arabinoside (Ara-C)
To determine optimal dosage, Dihydroxyanthracenedione (DHAD) was given once daily for 3 days at dosage levels of 6, 7, 8, and 10 mg/m2 in combination with a 7-day continuous infusion of cytosine arabinoside (Ara-...
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Article
613 ADRIAMYCIN AS A MAINTENANCE AGENT IN ACUTE LYMPHOBLASTIC LEUKEMIA
Adriamycin (ADM) in a low weekly dose (10mg/M2) was used as a single agent for maintenance of remission (RMS) in 24 previously treated children with acute lymphoblastic leukemia (ALL). The dose was escalated by 2...
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Article
THE REGULATION OF GRANULOPOIESIS IN CHILDHOOD NEUTROPENIC DISORDERS AND ACUTE LEUKEMIA
The agar culture technic for the growth of human granulocytic colony forming cells (or CFC) from the bone marrow of patients may be used to study factors involved in the regulation of granulopoiesis. Bone marr...