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Article
Open AccessAssociation between stop** renin-angiotensin system inhibitors immediately before hemodialysis initiation and subsequent cardiovascular events
It is controversial whether renin-angiotensin system inhibitors (RASIs) should be stopped in patients with advanced chronic kidney disease (CKD). Recently, it was reported that stop** RASIs in advanced CKD w...
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Article
Sodium zirconium cyclosilicate reconciles management of hyperkalemia and continuity of renin–angiotensin–aldosterone system inhibitors: a retrospective observational study
Sodium zirconium cyclosilicate, a non-absorbed non-polymer zirconium silicate, is a new potassium binder for hyperkalemia. A previous report showed that administering sodium zirconium cyclosilicate to patients...
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Article
Open AccessEffects of iron-based phosphate binders on mortality and cardiovascular events in patients receiving maintenance dialysis
Phosphate binders are the main treatment for hyperphosphatemia in patients with chronic kidney disease, and iron-based phosphate binders have been used with increasing frequency in recent years. This study exa...
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Article
Relationship between serum sodium level at dialysis initiation and all-cause mortality
Hyponatremia is a common electrolyte disorder in patients with chronic kidney disease. In addition, hyponatremia is associated with mortality in patients with chronic kidney disease, including those on dialysi...
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Article
Prescription rate of erythropoietin-stimulating agents is low for patients with renal impairment under non-nephrology care in a tertiary-level academic medical center in Japan
Erythropoiesis-stimulating agents (ESAs) and iron supplements may be prescribed appropriately under nephrology care. However, there are few reports detailing the differences in prescription rates of these ther...
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Article
Sex differences in clinical outcomes in Japanese incident dialysis patients: a prospective observational multicenter study
A Dialysis Outcomes and Practice Patterns Study (DOPPS) has shown a one-to-one male-to-female mortality ratio, notwithstanding the statistically longer life expectancy of women in the general population. This ...
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Article
Open AccessFactors associated with aortic valve stenosis in Japanese patients with end-stage kidney disease
Aortic valve stenosis (AS) has a high prevalence and poor prognosis in patients who receive maintenance dialysis. However, few large-scale observational studies in Japan have investigated patients with AS who ...
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Article
Open AccessAuthor Correction: Analysis of O-glycoforms of the IgA1 hinge region by sequential deglycosylation
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Article
Open AccessRelationship between mortality and use of sodium bicarbonate at the time of dialysis initiation: a prospective observational study
Patients with chronic kidney disease often experience metabolic acidosis. Whether oral sodium bicarbonate can reduce mortality in patients with metabolic acidosis has been debated for years. Hence, this study ...
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Article
Open AccessFalse-negative diagnosis of high anion gap in patients with end-stage kidney disease
The traditional anion gap (AG) equation is widely used, but its misdiagnosis in end-stage kidney disease (ESKD) patients has not been investigated fully. Diagnostic accuracy to detect high AG was cross-section...
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Possible Biomarkers for Diabetic Kidney Disease
The prevalence of diabetes is increasing worldwide and is the highest in the Western Pacific region, which includes Japan. There is an urgent need for the development of new diabetic kidney disease (DKD) bioma...
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Article
Open AccessLong-term changes in renal function after treatment initiation and the importance of early diagnosis in maintaining renal function among IgG4-related tubulointerstitial nephritis patients in Japan
The present study aimed to investigate associations between long-term renal function, whether IgG4-related tubulointerstitial nephritis (TIN) was diagnosed by renal biopsy at initial examination, chronic kidne...
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Article
Open AccessComparison of the 2018 and 2003 International Society of Nephrology/Renal Pathology Society classification in terms of renal prognosis in patients of lupus nephritis: a retrospective cohort study
Although the 2018 revised International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification was proposed recently, until now, no reports have been made comparing the association of renal pro...
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Article
The impact of gender difference on the relationship between serum high-density lipoprotein level and cardiovascular events in incident dialysis patients: a multicenter prospective cohort study
This study aimed to clarify the relationship between serum high-density lipoprotein cholesterol (HDL-C) level and incidence of CV events. Moreover, the relationship stratified by gender was evaluated.
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Article
Open AccessAnalysis of O-glycoforms of the IgA1 hinge region by sequential deglycosylation
A common renal disease, immunoglobulin A (IgA) nephropathy (IgAN), is associated with glomerular deposition of IgA1-containing immune complexes. IgA1 hinge region (HR) has up to six clustered O-glycans consisting...
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Article
Effect of combined vitamin D receptor activator and lanthanum carbonate on serum fibroblast growth factor 23 level in predialysis patients (CVD-LAF study): design and method
Whether vitamin D receptor activator (VDRA) use is beneficial in chronic kidney disease (CKD) is unclear, because it is possible that VDRA increases serum fibroblast growth factor 23 (FGF23) levels. We will co...
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Article
Impact of high mortality in incident dialysis patients due to hypertensive nephrosclerosis: a multicenter prospective cohort study in Aichi, Japan
An increasing number of patients worldwide require dialysis as a result of hypertensive nephrosclerosis (HTN). However, in Japan, mortality in patients with end-stage renal disease (ESRD) has not been well by ...
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Article
Open AccessAortic stenosis is a risk factor for all-cause mortality in patients on dialysis: a multicenter prospective cohort analysis
Aortic stenosis (AS) is common in patients on dialysis as well as in the general population. AS leads to difficulty with dialysis therapy because of unstable conditions such as intradialytic hypotension due to...
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Article
Ratio of blood urea nitrogen to serum creatinine at initiation of dialysis is associated with mortality: a multicenter prospective cohort study
Some studies have shown that the estimated glomerular filtration rate (eGFR) at the time of initiating dialysis was associated with mortality. However, the relationship between ratio of blood urea nitrogen to ...
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Article
Open AccessUnfavorable effects of history of volume overload and late referral to a nephrologist on mortality in patients initiating dialysis: a multicenter prospective cohort study in Japan
Patients with late referral and positive history of volume overload may have a poor prognosis after initiating dialysis due to insufficient and/or inadequate management of complications of renal failure and th...
