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Article
Open AccessTolerable glycometabolic stress boosts cancer cell resilience through altered N-glycosylation and Notch signaling activation
Chronic metabolic stress paradoxically elicits pro-tumorigenic signals that facilitate cancer stem cell (CSC) development. Therefore, elucidating the metabolic sensing and signaling mechanisms governing cancer...
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Article
Open AccessHigher-order rich-club phenomenon in collaborative research grant networks
Modern scientific work, including writing papers and submitting research grant proposals, increasingly involves researchers from different institutions. In grant collaborations, it is known that institutions i...
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Chapter and Conference Paper
Random Hypergraph Model Preserving Two-Mode Clustering Coefficient
Real-world complex systems often involve interactions among more than two nodes, and such complex systems can be represented by hypergraphs. Comparison between a given hypergraph and randomized hypergraphs tha...
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Article
Open AccessAuthor Correction: Analysis of O-glycoforms of the IgA1 hinge region by sequential deglycosylation
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Article
High-throughput N-glycan screening method for therapeutic antibodies using a microchip-based DNA analyzer: a promising methodology for monitoring monoclonal antibody N-glycosylation
N-Glycosylation of therapeutic antibodies is a critical quality attribute (CQA), and the micro-heterogeneity affects the biological and physicochemical properties of antibodies. Therefore, the profiling of N-glyc...
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Article
Open AccessMeasurement error of network clustering coefficients under randomly missing nodes
The measurement error of the network topology caused by missing network data during the collection process is a major concern in analyzing collected network data. It is essential to clarify the error between t...
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Article
Open AccessAnalysis of O-glycoforms of the IgA1 hinge region by sequential deglycosylation
A common renal disease, immunoglobulin A (IgA) nephropathy (IgAN), is associated with glomerular deposition of IgA1-containing immune complexes. IgA1 hinge region (HR) has up to six clustered O-glycans consisting...
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Chapter
Structural Analysis of Glycans (Analytical and Detection Methods)
Glycoprotein, Glycolipid, Structural characterization
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Reference Work Entry In depth
Profiling of Glucosylceramides by Liquid Chromatography-Tandem Mass Spectrometry
Cell membrane surface glycosphingolipids (GSLs), which are synthesized from glucosylceramide (GlcCer) by the enzymatic action of glucosylceramide synthase (GlcT-1), play fundamental roles in many cellular proc...
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Reference Work Entry In depth
Simultaneous Quantification of Nucleotide Sugar Metabolism by LC and LC-MS
Cellular glycosylation plays an important role in many biological processes, as well as in disease states such as diabetes and cancer. Nucleotide sugar s are donor substrates of glycosyltransferases and their ...
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Living Reference Work Entry In depth
Profiling of Glucosylceramides by Liquid Chromatography-Tandem Mass Spectrometry
Cell membrane surface glycosphingolipids (GSLs), which are synthesized from glucosylceramide (GlcCer) by the enzymatic action of glucosylceramide synthase (GlcT-1), play fundamental roles in many cellular proc...
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Living Reference Work Entry In depth
Simultaneous Quantification of Nucleotide Sugar Metabolism by LC and LC-MS
Cellular glycosylation plays an important role in many biological processes, as well as in disease states such as diabetes and cancer. Nucleotide sugar s are donor substrates of glycosyltransferases and their ...
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Article
Structural Characterization of Monosialo-, Disialo- and Trisialo-gangliosides by Negative Ion AP-MALDI-QIT-TOF Mass Spectrometry with MSn Switching
The atmospheric pressure matrix-assisted laser desorption/ionization (AP-MALDI) is a quite convenient soft ionization for biomolecules, kee** analytes atmospheric conditions instead of high vacuum conditions...
