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  1. Article

    Erratum: Augmented adenovirus transduction of murine T lymphocytes utilizing a bi-specific protein targeting murine interleukin 2 receptor

    Correction to: Cancer Gene Therapy (2013) 20, 445–452; doi:10.1038/cgt.2013.39; published online 9 August 2013 Laura Timares was unintentionally left off the list of authors. She should have been listed along ...

    M S Beatty, L Timares, D T Curiel in Cancer Gene Therapy (2015)

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    Gene therapy for radioprotection

    Radiation therapy is a critical component of cancer treatment with over half of patients receiving radiation during their treatment. Despite advances in image-guided therapy and dose fractionation, patients re...

    W H Everett, D T Curiel in Cancer Gene Therapy (2015)

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    Article

    Therapeutic adenoviral gene transfer of a glycosyltransferase for prevention of peritoneal dissemination and metastasis of gastric cancer

    Increased expression of sialyl Lewisx/a carbohydrates, ligands for E-selectin, correlates with clinically advanced stages and metastasis of gastric and colon cancers. In contrast, Sda carbohydrate is abundantly d...

    Y I Kawamura, Y Adachi, D T Curiel, R Kawashima, R Kannagi… in Cancer Gene Therapy (2014)

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    Article

    Experimental virotherapy of chemoresistant pancreatic carcinoma using infectivity-enhanced fiber-mosaic oncolytic adenovirus

    Pancreatic cancer is a significant clinical problem and novel therapeutic approaches are desperately needed. Recent advances in conditionally replicative adenovirus-based (CRAd) oncolytic virus design allow th...

    S A Kaliberov, L N Kaliberova, D J Buchsbaum, D T Curiel in Cancer Gene Therapy (2014)

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    Article

    Augmented adenovirus transduction of murine T lymphocytes utilizing a bi-specific protein targeting murine interleukin 2 receptor

    Adenoviruses are currently used in a variety of bench and bedside applications. However, their employment in gene delivery to lymphocyte lineages is hampered by the lack of coxsackie virus and adenovirus recep...

    M S Beatty, D T Curiel in Cancer Gene Therapy (2013)

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    A myeloid cell-binding adenovirus efficiently targets gene transfer to the lung and escapes liver tropism

    Specific and efficient gene delivery to the lung has been hampered by liver sequestration of adenovirus serotype 5 (Ad5) vectors. The complexity of Ad5 liver tropism has largely been unraveled, permitting impr...

    M O Alberti, J S Deshane, D D Chaplin, L Pereboeva, D T Curiel, J C Roth in Gene Therapy (2013)

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    Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) improves therapeutic efficacy in low CAR prostate cancer cells

    Gene therapy is being examined as a potential strategy for treating prostate cancer. Serotype 5 adenovirus (Ad.5) is routinely used as a vector for transgene delivery. However, the infectivity of Ad.5 is depen...

    R Dash, I Dmitriev, Z-z Su, S K Bhutia, B Azab, N Vozhilla, A Yacoub… in Cancer Gene Therapy (2010)

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    A cancer terminator virus eradicates both primary and distant human melanomas

    The prognosis and response to conventional therapies of malignant melanoma inversely correlate with disease progression. With increasing thickness, melanomas acquire metastatic potential and become inherently ...

    D Sarkar, Z-z Su, E-S Park, N Vozhilla, P Dent, D T Curiel… in Cancer Gene Therapy (2008)

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    Article

    Cell vehicle targeting strategies

    Use of cells as therapeutic carriers has increased in the past few years and has developed as a distinct concept and delivery method. Cell-based vehicles are particularly attractive for delivery of biotherapeu...

    J C Roth, D T Curiel, L Pereboeva in Gene Therapy (2008)

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    Tumor targeting carboxylesterase fused with anti-CEA scFv improve the anticancer effect with a less toxic dose of irinotecan

    Irinotecan (CPT-11) is a key drug for the treatment of various cancers. CPT-11 can be considered to be a prodrug, since it needs to be activated into the toxic drug SN-38 by the enzyme carboxylesterase. Howeve...

    J Uchino, K Takayama, A Harada, T Sone, T Harada, D T Curiel… in Cancer Gene Therapy (2008)

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    Article

    Significant alterations of biodistribution and immune responses in Balb/c mice administered with adenovirus targeted to CD40(+) cells

    CD40 ligation has been shown to promote antigen-presenting functions of dendritic cells, which express CD40 receptor. Here we reported significantly altered biodistribution and immune responses with the use of...

    D Huang, A V Pereboev, N Korokhov, R He, L Larocque, C Gravel, B Jaentschke… in Gene Therapy (2008)

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    Article

    Direct selection of targeted adenovirus vectors by random peptide display on the fiber knob

    Targeting of gene transfer at the level of cell entry is one of the most attractive challenges in vector development. However, attempts to redirect adenovirus vectors to alternative receptors by engineering th...

    Y Miura, K Yoshida, T Nishimoto, K Hatanaka, S Ohnami, M Asaka, J T Douglas… in Gene Therapy (2007)

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    Article

    Targeting EGFR with metabolically biotinylated fiber-mosaic adenovirus

    Adenovirus (Ad)-based vectors are useful gene delivery vehicles for a variety of applications. Despite their attractive properties, many in vivo applications require modulation of the viral tropism. Targeting app...

    L Pereboeva, S Komarova, J Roth, S Ponnazhagan, D T Curiel in Gene Therapy (2007)

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    Article

    A three-dimensional assay for measurement of viral-induced oncolysis

    Oncolytic viruses represent a novel cancer treatment strategy. Despite their promising preclinical data, however, corresponding clinical trials have disappointed. To aid preclinical analyses, we hypothesized t...

    J T Lam, A Hemminki, A Kanerva, K B Lee, J L Blackwell, R Desmond… in Cancer Gene Therapy (2007)

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    Article

    Directing adenovirus across the blood–brain barrier via melanotransferrin (P97) transcytosis pathway in an in vitro model

    Adenovirus serotype 5 (Ad5) is widely used in the development of gene therapy protocols. However, current gene therapy strategies involving brain are mostly based on intra-cranial injection. A major obstacle f...

    Y Tang, T Han, M Everts, Z B Zhu, G Y Gillespie, D T Curiel, H Wu in Gene Therapy (2007)

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    Article

    Vascular endothelial growth factor promoter-based conditionally replicative adenoviruses for pan-carcinoma application

    Treatment of advanced lung cancer is one of the major challenges in current medicine because of the high morbidity and mortality of the disease. Advanced stage lung cancer is refractory to conventional therapi...

    K Takayama, P N Reynolds, Y Adachi, L Kaliberova, J Uchino… in Cancer Gene Therapy (2007)

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    Article

    Transductional targeting of adenovirus vectors for gene therapy

    Cancer gene therapy approaches will derive considerable benefit from adenovirus (Ad) vectors capable of self-directed localization to neoplastic disease or immunomodulatory targets in vivo. The ablation of native...

    J N Glasgow, M Everts, D T Curiel in Cancer Gene Therapy (2006)

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    Article

    Gene therapy for carcinoma of the breast

    In view of the limited success of available treatment modalities for breast cancer, alternative and complementary strategies need to be developed. The delineation of the molecular basis of breast cancer provid...

    M A Stoff-Khalili, P Dall, D T Curiel in Cancer Gene Therapy (2006)

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    Article

    Employment of liver tissue slice analysis to assay hepatotoxicity linked to replicative and nonreplicative adenoviral agents

    Whereas virotherapy has emerged as a novel and promising approach for neoplastic diseases, appropriate model systems have hampered preclinical evaluation of candidate conditionally replicative adenovirus agent...

    M A Stoff-Khalili, A A Rivera, L P Le, A Stoff, M Everts… in Cancer Gene Therapy (2006)

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    Article

    Infectivity enhancement for adenoviral transduction of canine osteosarcoma cells

    The full realization of conditionally replicative adenoviruses (CRAds) for cancer therapy has been hampered by the limited knowledge of CRAd function in vivo and particularly in an immunocompetent host. To addres...

    L P Le, A A Rivera, J N Glasgow, V V Ternovoi, H Wu, M Wang, B F Smith… in Gene Therapy (2006)

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