16 Result(s)

Article

Safety and efficacy of PD-1/PD-L1 blockade in patients with preexisting antinuclear antibodies

Immune checkpoint inhibitors (ICIs) show promising clinical activity in advanced cancers. However, the safety and efficacy of PD-1/PD-L1 blockade in patients with preexisting antinuclear antibodies (ANA) are u...

T. Sakakida, T. Ishikawa, Y. Chihara, S. Harita… in Clinical and Translational Oncology (2020)

Article

Tumor targeting carboxylesterase fused with anti-CEA scFv improve the anticancer effect with a less toxic dose of irinotecan

Irinotecan (CPT-11) is a key drug for the treatment of various cancers. CPT-11 can be considered to be a prodrug, since it needs to be activated into the toxic drug SN-38 by the enzyme carboxylesterase. Howeve...

J Uchino, K Takayama, A Harada, T Sone, T Harada, D T Curiel… in Cancer Gene Therapy (2008)

Article

Vascular endothelial growth factor promoter-based conditionally replicative adenoviruses for pan-carcinoma application

Treatment of advanced lung cancer is one of the major challenges in current medicine because of the high morbidity and mortality of the disease. Advanced stage lung cancer is refractory to conventional therapi...

K Takayama, P N Reynolds, Y Adachi, L Kaliberova, J Uchino… in Cancer Gene Therapy (2007)

Article

Prevention of radiation-induced pneumonitis by recombinant adenovirus-mediated transferring of soluble TGF-β type II receptor gene

To investigate whether radiation-induced pneumonitis in the mouse-irradiated lung could be prevented by recombinant adenovirus-mediated soluble transforming growth factor-beta (TGF-β) type II receptor gene therap...

Z Hai**, K Takayama, J Uchino, A Harada, Y Adachi, S Kura… in Cancer Gene Therapy (2006)

Article

Transverse colonic stenosis

A 3-year child presented with episodic lower abdominal pain; during the eighth attack, a mass was palpable in the left upper quadrant, and a barium enema revealed a stenotic area in the transverse colon. This...

M. Takahashi, F. Sasaki, T. Namieno, T. Matsuhisa… in Pediatric Surgery International (1998)

Article

Imaging diagnosis of alveolar echinococcosis in young patients

We review the imaging findings in seven children with alveolar echinococcosis of the liver. Calcification was seen on plain abdominal films in five of seven patients (66.6 %); the calcifications were small or...

F. Sasaki, Y. Ohkawa, N. Sato, J. Uchino, Y. Hata in Pediatric Radiology (1997)

Article

Positive effect of tamoxifen as part of adjuvant chemo-endocrine therapy for breast cancer

A prospective randomised multicentre clinical study was undertaken for 2 years and 3 months from November 1982, with the aim of examining the significance of using a combination of ftorafur (FT) and tamoxifen ...

J Uchino, N Samejima, T Tanabe, H Hayasaka, M Mito, Y Hata… in British Journal of Cancer (1994)

Article

Fetal liver-cell transplantation for surgically-induced acute hepatic failure in rats

Pediatric liver transplantation has become increasingly successful, but donor scarcity is a major limitation. We studied fetal liver-cell transplantation as an alternative to provide functional hepatic replace...

Y. Hata, T. Hase, Y. Yoshikawa, F. Sasaki, H. Takahashi… in Pediatric Surgery International (1993)

Article

Liver regeneration following portacaval shunt in rats: 3′, 5′-cyclic AMP changes in plasma and liver tissue

Hepatic regeneration following portacaval shunt was evaluated in the light of the changes of 3′, 5′-cyclic AMP (cAMP) levels in plasma and liver tissue, and also plasma cAMP levels after glucagon administratio...

Y. Hata, Y. Yoshikawa, Y. Une, F. Sasaki, Y. Nakajima… in Research in Experimental Medicine (1992)

Article

Fetal bile acids in congenital biliary atresia —production in the liver and clinical significance

The 1β-hydroxy bile acids have been said to be fetal bile acids. These bile acids were evaluated in eight patients with congenital biliary atresia (CBA) using gas chromatography-mass spectrometry. At the time ...

Y. Hata, J. Uchino, F. Sasaki, T. Abe, Y. Koike, S. Alam… in Pediatric Surgery International (1991)

Article

Aspects chirurgicaux de la segmentation des veines hépatiques basés sur la veinographie hépatique

Nous pensons que nous devons clairement préciser non seulement la distribution des branches de la v. porte, mais aussi celle des v. hépatiques drainant une tumeur afin de faciliter au mieux la résection hépati...

Y. Hata, J. Uchino, Y. Une, Y. Morita in Surgical and Radiologic Anatomy (1989)

Article

Surgical aspects of hepatic segmentation based on hepatic venographies

Hepatic venographies were performed selectively in 42 patients with hepatocarcinoma. The findings were evaluated from anterior and lateral views. Thirty-nine right hepatic v. could be identified and the existe...

Y. Hata, J. Uchino, Y. Une, Y. Morita in Surgical and Radiologic Anatomy (1989)

Article

Solid and cystic tumor of the pancreas in a child

A solid and cystic tumor of the pancreas in a 10-year-old girl was removed completely by pancreatectomy. Immunohistochemical and electron microscopic examinations disclosed acinar cell origin. Thirteen collect...

Y. Hata, F. Sasaki, S. Alam, Y. Koike, T. Namieno… in Pediatric Surgery International (1989)

Article

Proceedings of the 27th Annual Meeting Matsuyama, Japan, November 7–9, 1985

C. E. Rogler, Yoshihiro Muto, Masayuki Uchimura… in Gastroenterologia Japonica (1986)

Article

Proceedings of the 71st General Meeting Sapporo, Japan, May 22–24, 1985

Masafumi Suyama, Jo Ariyama, Shunsaku Higashi, Ryuji Mizumoto… in Gastroenterologia Japonica (1986)