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Article
Open AccessCorrection: RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas
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Article
Open AccessRET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas
It is unclear how loss-of-function germline mutations in the widely-expressed co-chaperone AIP, result in young-onset growth hormone secreting pituitary tumours. The RET receptor, uniquely co-expressed in somatot...
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Article
TGF-β-induced apoptosis in human thyrocytes is mediated by p27kip1 reduction and is overridden in neoplastic thyrocytes by NF-κB activation
Millions of people worldwide suffer goiter, a proliferative disease of the follicular cells of the thyroid that may become neoplastic. Thyroid neoplasms have low proliferative index, low apoptotic index and a ...
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Article
TGF-β1 actions on FRTL-5 cells provide a model for the physiological regulation of thyroid growth
Little is known about the TGF-β1 mechanism that promotes thyroid cell growth arrest. We assessed TGF-β1 effects on Fisher rat thyroid cell line (FRTL-5). This allowed us to study TGF-β1 action on thyroid cells...