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Article
Open AccessEffective Apixaban removal using hemoadsorption during emergent open-heart surgery: a case report and narrative literature review
The management of hemostasis in patients medicated with apixaban (Eliquis) undergoing emergency cardiac surgery is exceedingly difficult. The body’s natural elimination pathways for apixaban prove ineffective ...
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Article
Open AccessExperiencing Data on Location: A Case Study of Visualizing Air Quality for Citizens
Visualizing urban data has different purposes. Besides more traditional goals such as supporting experts to decide on smart city policies, supporting citizens to understand aspects of the city relevant to one’...
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Article
An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma
Treating patients who have cancer with vaccines that stimulate a targeted immune response is conceptually appealing, but cancer vaccine trials have not been successful in late-stage patients with treatment-ref...
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Article
Treatment of blepharospasm and Meige’s syndrome with abo- and onabotulinumtoxinA: long-term safety and efficacy in daily clinical practice
Thirty years after their approval, botulinum toxin injections still are the first-line therapy for blepharospasm. The aim of our study was to analyze long-term data concerning safety and efficacy in a large co...
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Article
Open AccessDesign-features of bubble-prone experimental asset markets with a constant FV
Experimental asset markets with a constant fundamental value (\(\mathrm {\textsc {fv}}\)FV) have grown in importance in recent years. A methodological examination of the robustness of experimental results in such...
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Article
Interaktive Lichtvisualisierung zur Aufdeckung von Lecklichteffekten
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Article
Interactive Light Visualization for the Detection of Leakage Light Effects
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Article
Open AccessScale matters: risk perception, return expectations, and investment propensity under different scalings
With a novel experimental design we investigate whether risk perception, return expectations, and investment propensity are influenced by the scale of the vertical axis in charts. We explore this for two prese...
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Article
Publisher Correction: Actively personalized vaccination trial for newly diagnosed glioblastoma
The additional author support information was erroneously omitted from the Supplementary Information. This has been corrected online.
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Chapter
Concrete Methods and Case Experiences with Theme-Centered Interaction
Higher education is an important time of life, individually for the young adults and sociologically for a society which lives by the capacities of the coming generations. Therefore we need the best education n...
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Article
Actively personalized vaccination trial for newly diagnosed glioblastoma
Patients with glioblastoma currently do not sufficiently benefit from recent breakthroughs in cancer treatment that use checkpoint inhibitors1,2. For treatments using checkpoint inhibitors to be successful, a hig...
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Article
PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing
The sensing of microbial genetic material by leukocytes often elicits beneficial pro-inflammatory cytokines, but dysregulated responses can cause severe pathogenesis. Genome-wide association studies have linke...
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Chapter and Conference Paper
A New Process to Evaluate the Risk of an Engine Power Drop Caused by Snow Particles
In cold and snowy regions roads are often covered with snow during the winter time. On these roads snow particles can be rolled up by vehicles and these particles can penetrate into the air intake system of th...
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Article
Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer
The authors report the first-in-human application of personalized neo-antigen RNA vaccines in patients with melanoma.
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Article
Open AccessPitfalls in TAMVI: experience with the repositionable Lotus® Valve System
Simultaneous transapical implantation of transcatheter heart valves in the native mitral and aortic position may be considered as an alternative to surgical valve replacement in high-risk patients presenting w...
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Protocol
The European Regulatory Environment of RNA-Based Vaccines
A variety of different mRNA-based drugs are currently in development. This became possible, since major breakthroughs in RNA research during the last decades allowed impressive improvements of translation, sta...
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Article
Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
The development of a nanoparticle RNA vaccine is reported that preferentially targets dendritic cells after systemic administration, and is shown to provide durable interferon-α-dependent antigen-specific immu...
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Article
Erratum: Mutant MHC class II epitopes drive therapeutic immune responses to cancer
Nature 520, 692–696 (2015); doi:10.1038/nature14426 In this Letter, there were minor formatting errors in the poly‐neo‐epitope RNA in Fig. 3a, which occurred during the production process; this figure has been...
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Article
Mutant MHC class II epitopes drive therapeutic immune responses to cancer
The authors show that a large fraction of tumour mutations is immunogenic and predominantly recognized by CD4+ T cells; they use these data to design synthetic messenger-RNA-based vaccines specific against tumour...
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Article
Therapeutic vaccines for cancer: an overview of clinical trials
Development of vaccines for the treatment of cancer has posed many challenges, but results from some recent studies have confirmed the potential for clinical b...
