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  1. Article

    Open Access

    Form factor determination of biological molecules with X-ray free electron laser small-angle scattering (XFEL-SAS)

    Free-electron lasers (FEL) are revolutionizing X-ray-based structural biology methods. While protein crystallography is already routinely performed at FELs, Small Angle X-ray Scattering (SAXS) studies of biolo...

    Clement E. Blanchet, Adam Round, Haydyn D. T. Mertens in Communications Biology (2023)

  2. Article

    Open Access

    Quantitative size-resolved characterization of mRNA nanoparticles by in-line coupling of asymmetrical-flow field-flow fractionation with small angle X-ray scattering

    We present a generically applicable approach to determine an extensive set of size-dependent critical quality attributes inside nanoparticulate pharmaceutical products. By coupling asymmetrical-flow field-flow...

    Melissa A. Graewert, Christoph Wilhelmy, Tijana Bacic in Scientific Reports (2023)

  3. Article

    Open Access

    Iodine-124 PET quantification of organ-specific delivery and expression of NIS-encoding RNA

    RNA-based vaccination strategies tailoring immune response to specific reactions have become an important pillar for a broad range of applications. Recently, the use of lipid-based nanoparticles opened the pos...

    Matthias Miederer, Stefanie Pektor, Isabelle Miederer, Nicole Bausbacher in EJNMMI Research (2021)

  4. No Access

    Article

    An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma

    Treating patients who have cancer with vaccines that stimulate a targeted immune response is conceptually appealing, but cancer vaccine trials have not been successful in late-stage patients with treatment-ref...

    Ugur Sahin, Petra Oehm, Evelyna Derhovanessian, Robert A. Jabulowsky in Nature (2020)

  5. No Access

    Article

    Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

    The development of a nanoparticle RNA vaccine is reported that preferentially targets dendritic cells after systemic administration, and is shown to provide durable interferon-α-dependent antigen-specific immu...

    Lena M. Kranz, Mustafa Diken, Heinrich Haas, Sebastian Kreiter, Carmen Loquai in Nature (2016)

  6. No Access

    Chapter

    New Diagnostic and Therapeutic Options for the Treatment of Multiple Sclerosis

    Multiple sclerosis (MS) is a multifactorial disease and its treatment can be based on different strategies. We are presently approaching the MS problem at three different levels: (1) Develo** new carrier sys...

    Paolo Riccio, Heinrich Haas, Grazia Maria Liuzzi in Clinical Applications of Immunomics (2009)

  7. No Access

    Article

    Zur Trennung des Zinns und des Titans

    Heinrich Haas, Lucien Lévy in Zeitschrift für analytische Chemie (1890)