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Article
In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice
Transplantation of B cells engineered ex vivo to secrete broadly neutralizing antibodies (bNAbs) has shown efficacy in disease models. However, clinical translation of this approach would require specialized m...
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Article
Open AccessAuthor Correction: A pandemic-enabled comparison of discovery platforms demonstrates a naïve antibody library can match the best immune-sourced antibodies
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Article
Open AccessA pandemic-enabled comparison of discovery platforms demonstrates a naïve antibody library can match the best immune-sourced antibodies
As a result of the SARS-CoV-2 pandemic numerous scientific groups have generated antibodies against a single target: the CoV-2 spike antigen. This has provided an unprecedented opportunity to compare the effic...
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Article
Open AccessCleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors
Phospholipase D3 (PLD3) and PLD4 polymorphisms have been associated with several important inflammatory diseases. Here, we show that PLD3 and PLD4 digest ssRNA in addition to ssDNA as reported previously. More...
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Article
Open AccessCross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection
Pre-existing immunity to seasonal endemic coronaviruses could have profound consequences for antibody responses to SARS-CoV-2, induced from natural infection or vaccination. A first step to establish whether p...
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Open AccessAuthor Correction: Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20304-y
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Article
Open AccessVaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells
HIV broadly neutralizing antibodies (bnAbs) can suppress viremia and protect against HIV infection. However, their elicitation is made difficult by low frequencies of appropriate precursor B cell receptors and...
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Article
PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing
The sensing of microbial genetic material by leukocytes often elicits beneficial pro-inflammatory cytokines, but dysregulated responses can cause severe pathogenesis. Genome-wide association studies have linke...
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Article
Open AccessRIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome
Necroptosis is a type of programmed cell death with great significance in many pathological processes. Tumour necrosis factor-α(TNF), a proinflammatory cytokine, is a prototypic trigger of necroptosis. It is k...
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Article
Open AccessTranslocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death
Mixed lineage kinase domain-like protein (MLKL) was identified to function downstream of receptor interacting protein 3 (RIP3) in tumor necrosis factor-α (TNF)-induced necrosis (also called necroptosis). Howev...
