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Article
Author Correction: Enhancing untargeted metabolomics using metadata-based source annotation
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Article
Enhancing untargeted metabolomics using metadata-based source annotation
Human untargeted metabolomics studies annotate only ~10% of molecular features. We introduce reference-data-driven analysis to match metabolomics tandem mass spectrometry (MS/MS) data against metadata-annotate...
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Article
Open AccessReference materials for MS-based untargeted metabolomics and lipidomics: a review by the metabolomics quality assurance and quality control consortium (mQACC)
The metabolomics quality assurance and quality control consortium (mQACC) is enabling the identification, development, prioritization, and promotion of suitable reference materials (RMs) to be used in quality ...
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Article
Open AccessWorkshop report: Toward the development of a human whole stool reference material for metabolomic and metagenomic gut microbiome measurements
To date, there has been little effort to develop standards for metabolome-based gut microbiome measurements despite the significant efforts toward standard development for DNA-based microbiome measurements.
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Article
Nontargeted lipidomics of novel human plasma reference materials: hypertriglyceridemic, diabetic, and African-American
The unavailability of appropriate quality assurance/quality control materials in many lipidomics applications poses a significant challenge for lipidomics research. It is recommended that samples with certifie...
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Article
Dissemination and analysis of the quality assurance (QA) and quality control (QC) practices of LC–MS based untargeted metabolomics practitioners
The metabolomics quality assurance and quality control consortium (mQACC) evolved from the recognized need for a community-wide consensus on improving and systematizing quality assurance (QA) and quality contr...
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Article
Open AccessDetection of pathogenic Escherichia coli on potentially contaminated beef carcasses using cassette PCR and conventional PCR
Over a one year period, swabs of 820 beef carcasses were tested for the presence of Shiga toxin-producing Escherichia coli by performing Polymerase Chain Reaction (PCR) in a novel technology termed “cassette PCR”...
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Article
Lipidomics for wildlife disease etiology and biomarker discovery: a case study of pansteatitis outbreak in South Africa
Lipidomics is an emerging field with great promise for biomarker and mechanistic studies due to lipids diverse biological roles. Clinical research applying lipidomics is drastically increasing, with research m...
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Article
NIST lipidomics workflow questionnaire: an assessment of community-wide methodologies and perspectives
Efforts to harmonize lipidomic methodologies have been limited within the community. Here, we aimed to capitalize on the recent National Institute of Standards and Technology lipidomics interlaboratory compari...
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Article
Open AccessPrinting of small molecular medicines from the vapor phase
There is growing need to develop efficient methods for early-stage drug discovery, continuous manufacturing of drug delivery vehicles, and ultra-precise dosing of high potency drugs. Here we demonstrate the us...
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Article
Comparison of Ambient and Atmospheric Pressure Ion Sources for Cystic Fibrosis Exhaled Breath Condensate Ion Mobility-Mass Spectrometry Metabolomics
Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The vast majority of the mortality i...
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Article
Open AccessHighly-accurate metabolomic detection of early-stage ovarian cancer
High performance mass spectrometry was employed to interrogate the serum metabolome of early-stage ovarian cancer (OC) patients and age-matched control women. The resulting spectral features were used to estab...
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Protocol
Metabolite Profiling by Direct Analysis in Real-Time Mass Spectrometry
Untargeted metabolite profiling is a discovery tool for the identification of metabolites associated with the responses of perturbations to biological systems, such as a disease. Direct analysis in real-time m...
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Article
Map** cell fate decisions that occur during soybean defense responses
The soybean defense response to the soybean cyst nematode was used as a model to map at cellular resolution its genotype-defined cell fate decisions occurring during its resistant reactions. The defense respon...
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Article
Determination of Enantiomeric Compositions of Analytes Using Novel Fluorescent Chiral Molecular Micelles and Steady State Fluorescence Measurements
Novel fluorescent chiral molecular micelles (FCMMs) were synthesized, characterized, and employed as chiral selectors for enantiomeric recognition of non-fluorescent chiral molecules using steady state fluores...
