-
Article
Open AccessExploring the genetics of lithium response in bipolar disorders
Lithium (Li) remains the treatment of choice for bipolar disorders (BP). Its mood-stabilizing effects help reduce the long-term burden of mania, depression and suicide risk in patients with BP. It also has bee...
-
Article
Open AccessFocal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis
Lithium (Li) is one of the most effective drugs for treating bipolar disorder (BD), however, there is presently no way to predict response to guide treatment. The aim of this study is to identify functional ge...
-
Article
Open AccessOpen access repository-scale propagated nearest neighbor suspect spectral library for untargeted metabolomics
Despite the increasing availability of tandem mass spectrometry (MS/MS) community spectral libraries for untargeted metabolomics over the past decade, the majority of acquired MS/MS spectra remain uninterprete...
-
Article
Open AccessAssociation of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder
Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consiste...
-
Article
Open AccessDifferential characteristics of bipolar I and II disorders: a retrospective, cross-sectional evaluation of clinical features, illness course, and response to treatment
The distinction between bipolar I and bipolar II disorder and its treatment implications have been a matter of ongoing debate. The aim of this study was to examine differences between patients with bipolar I a...
-
Article
Open AccessExploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder
Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both develo** and adult brains. However, many people l...
-
Article
Guiding the choice of informatics software and tools for lipidomics research applications
Progress in mass spectrometry lipidomics has led to a rapid proliferation of studies across biology and biomedicine. These generate extremely large raw datasets requiring sophisticated solutions to support aut...
-
Article
Open AccessCorrection: Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients
-
Article
Open AccessCombining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients
Lithium is the gold standard therapy for Bipolar Disorder (BD) but its effectiveness differs widely between individuals. The molecular mechanisms underlying treatment response heterogeneity are not well unders...
-
Article
Open AccessThe growing need for controlled data access models in clinical proteomics and metabolomics
More and more clinical studies include potentially sensitive human proteomics or metabolomics datasets, but bioinformatics resources for managing the access to these data are not yet available. This commentary...
-
Article
Open AccessHLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders
Bipolar affective disorder (BD) is a severe psychiatric illness, for which lithium (Li) is the gold standard for acute and maintenance therapies. The therapeutic response to Li in BD is heterogeneous and relia...
-
Article
Open AccessVariations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder
Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous exploratory study of patients with bipolar I disorder, we found that a history of suicide attempts w...
-
Article
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder
Lithium is a first-line medication for bipolar disorder (BD), but only one in three patients respond optimally to the drug. Since evidence shows a strong clinical and genetic overlap between depression and bip...
-
Article
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 6...
-
Article
Open AccessPrediction of lithium response using genomic data
Predicting lithium response prior to treatment could both expedite therapy and avoid exposure to side effects. Since lithium responsiveness may be heritable, its predictability based on genomic data is of inte...
-
Article
Open AccessExemplar scoring identifies genetically separable phenotypes of lithium responsive bipolar disorder
Predicting lithium response (LiR) in bipolar disorder (BD) may inform treatment planning, but phenotypic heterogeneity complicates discovery of genomic markers. We hypothesized that patients with “exemplary ph...
-
Article
Dissemination and analysis of the quality assurance (QA) and quality control (QC) practices of LC–MS based untargeted metabolomics practitioners
The metabolomics quality assurance and quality control consortium (mQACC) evolved from the recognized need for a community-wide consensus on improving and systematizing quality assurance (QA) and quality contr...
-
Article
Open AccessThe CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens
The Critical Assessment of Functional Annotation (CAFA) is an ongoing, global, community-driven effort to evaluate and improve the computational annotation of protein function.
-
Article
Genome-wide association study identifies 30 loci associated with bipolar disorder
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 v...
-
Article
Towards quality assurance and quality control in untargeted metabolomics studies
We describe here the agreed upon first development steps and priority objectives of a community engagement effort to address current challenges in quality assurance (QA) and quality control (QC) in untargeted ...
