35 Result(s)
within
Christian Bode
English
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Article
Open Access“Dosis sola facit venenum”—Evidence for causality in the association between ketamine and cholestatic liver injury
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Open AccessNon-occlusive mesenteric ischemia and intra-arterial vasodilatory therapy in severe shock and multi-organ failure: treating the untreatable?
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Open AccessCarboxyhemoglobin predicts oxygenator performance and imminent oxygenator change in extracorporeal membrane oxygenation
The continuous exposure of blood to a non-biological surface during extracorporeal membrane oxygenation (ECMO) may lead to progressive thrombus formation in the oxygenator, hemolysis and consequently impaired ...
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Article
Open AccessCurrent clinical practice in using adjunctive extracorporeal blood purification in sepsis and septic shock: results from the ESICM “EXPLORATION” survey
Despite a lack of clear evidence extracorporeal blood purification (EBP) is increasingly used as an adjunctive treatment in septic shock based on its biological plausibility. However, current state of praxis a...
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Open AccessTargeting the host response in sepsis: current approaches and future evidence
Sepsis, a dysregulated host response to infection characterized by organ failure, is one of the leading causes of death worldwide. Disbalances of the immune response play an important role in its pathophysiolo...
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Article
D-dimer trends in ECMO patients: don’t shoot the messenger
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Open AccessImmunosuppressive effects of circulating bile acids in human endotoxemia and septic shock: patients with liver failure are at risk
Sepsis-induced immunosuppression is a frequent cause of opportunistic infections and death in critically ill patients. A better understanding of the underlying mechanisms is needed to develop targeted therapie...
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Open AccessBridging patients with acute-on-chronic liver failure for transplantation: plasma exchange to stabilize multiorgan failure?
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Open AccessIncurring detriments of unplanned readmission to the intensive care unit following surgery for brain metastasis
Postoperative intensive care unit (ICU) monitoring is a common regime after neurosurgical resection of brain metastasis (BM). In comparison, unplanned secondary readmission to the ICU after initial postoperati...
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Open AccessReduced anticoagulation strategy is associated with a lower incidence of intracerebral hemorrhage in COVID-19 patients on extracorporeal membrane oxygenation
Optimal anticoagulation strategies for COVID-19 patients with the acute respiratory distress syndrome (ARDS) on venovenous extracorporeal membrane oxygenation (VV ECMO) remain uncertain. A higher incidence of ...
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Article
Open AccessPostoperative prolonged mechanical ventilation in patients with surgically treated pyogenic spondylodiscitis: a surrogate endpoint for early postoperative mortality
Surgical procedures with spinal instrumentation constitute a prevalent and occasionally highly indicated treatment modality in patients with pyogenic spondylodiscitis (PSD). However, surgical therapy might be ...
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Article
Open AccessEXCHANGE-2: investigating the efficacy of add-on plasma exchange as an adjunctive strategy against septic shock—a study protocol for a randomized, prospective, multicenter, open-label, controlled, parallel-group trial
Sepsis is as a life-threatening organ dysfunction caused by a dysregulated host response to an infection. The mortality of sepsis and particular of septic shock is very high. Treatment mostly focuses on infect...
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Open AccessLetter to the Editor: Innovative future concepts of extracorporeal strategies in sepsis and septic shock
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Article
Open AccessUnplanned intensive care unit readmission after surgical treatment in patients with newly diagnosed glioblastoma — forfeiture of surgically achieved advantages?
Postoperative intensive care unit (ICU) monitoring is an established option to ensure patient safety after resection of newly diagnosed glioblastoma. In contrast, secondary unplanned ICU readmission following ...
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Article
Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19
Anorexia and fasting are host adaptations to acute infection, and induce a metabolic switch towards ketogenesis and the production of ketone bodies, including β-hydroxybutyrate (BHB)1–6. However, whether ketogene...
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Open AccessMicrobe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening
The mechanisms linking systemic infection to hyperinflammation and immune dysfunction in sepsis are poorly understood. Extracellular histones promote sepsis pathology, but their source and mechanism of action ...
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Article
Where is the imperceptible difference?
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Open AccessClinical and biochemical endpoints and predictors of response to plasma exchange in septic shock: results from a randomized controlled trial
Recently, a randomized controlled trial (RCT) demonstrated rapid but individually variable hemodynamic improvement with therapeutic plasma exchange (TPE) in patients with septic shock. Prediction of clinical e...
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Article
It takes two to bleed: anticoagulation intensity and the host’s vascular susceptibility
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Immunomodulation by Tetracyclines in the Critically Ill: An Emerging Treatment Option?
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2022. Other selected articles can be found online at https://www.biomedcentral.com/coll...
