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Article
Open AccessRNA N6-methyladenosine modification-based biomarkers for absorbed ionizing radiation dose estimation
Radiation triage and biological dosimetry are critical for the medical management of massive potentially exposed individuals following radiological accidents. Here, we performed a genome-wide screening of radi...
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Article
Open AccessMid-Miocene sea level altitude of the Qaidam Basin, northern Tibetan Plateau
A detailed uplift history of the Tibetan Plateau is essential for disentangling the proposed geodynamical models and assessing its impacts on climate and biodiversity. However, when and how the plateau formed ...
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Chapter and Conference Paper
A Clothing Classification Network with Manifold Structure Based on Second-Order Convolution
Currently, AI-based clothing image classification techniques mostly use traditional deep learning methods, which are based on monocular clothing images for classification. However, the diversity of perspective...
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Article
Open AccessA single-cell atlas of the multicellular ecosystem of primary and metastatic hepatocellular carcinoma
Hepatocellular carcinoma (HCC) represents a paradigm of the relation between tumor microenvironment (TME) and tumor development. Here, we generate a single-cell atlas of the multicellular ecosystem of HCC from...
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Article
Open AccessLate Oligocene Melia (Meliaceae) from the Nanning Basin of South China and it’s biogeographical implication
Melia L. is a small genus of only 2–3 species, which is native to Indo-Malesia, India, Pakistan and southern parts of tropical Africa. Fossil records of Melia are known from the early Miocene to the Pleistocene. ...
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Article
Open AccessCharacterization of structural variation in Tibetans reveals new evidence of high-altitude adaptation and introgression
Structural variation (SV) acts as an essential mutational force sha** the evolution and function of the human genome. However, few studies have examined the role of SVs in high-altitude adaptation and little...
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Article
Open AccessUncovering the cognitive processes underlying mental rotation: an eye-movement study
Mental rotation is an important paradigm for spatial ability. Mental-rotation tasks are assumed to involve five or three sequential cognitive-processing states, though this has not been demonstrated experiment...
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Article
Open AccessMummified Oligocene fruits of Schima (Theaceae) and their systematic and biogeographic implications
The genus Schima includes about 20 species and is distributed only in southern China and adjacent areas of Asia. The previous molecular phylogenetic analysis suggested Schima is in the tribe Gordoniae, along with...
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Article
Camellia nanningensis sp. nov.: the earliest fossil wood record of the genus Camellia (Theaceae) from East Asia
A new species Camellia nanningensis was described on the basis of well-preserved mummified wood from the upper Oligocene Yongning Formation of Nanning Basin in Guangxi Province, South China. This represents the m...
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Article
Open AccessFirst record of Podocarpoid fossil wood in South China
A new species of fossil conifer wood, Podocarpoxylon donghuaiense sp. nov., is described from the late Eocene of Nadu Formation in Baise Basin of the Guangxi Province, South China. This fossil wood is characteriz...
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Article
First Oligocene mummified plant Lagerstätte at the low latitudes of East Asia
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Article
First fossil record of Staphylea L. (Staphyleaceae) from North America, and its biogeographic implications
The occurrences of Staphylea L. (Staphyleaceae) fossils have been abundantly documented from the Cenozoic of Eurasia, but none has been confirmed from North America to date. In this study, we describe Staphylea ...
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Article
Combined effects of the BDNF rs6265 (Val66Met) polymorphism and environment risk factors on psoriasis vulgaris
Smoking, alcohol consumption and higher body mass index (BMI) are well established risk factors for psoriasis and also associated with the clinical traits of the disease. And the genetic influences on these th...
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Article
Open AccessMiocene shift of European atmospheric circulation from trade wind to westerlies
The modern European climatic regime is peculiar, due to its unitary winter but diverse summer climates and a pronounced Mediterranean climate in the south. However, little is known on its evolution in the deep...
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Article
A large-scale screen for coding variants predisposing to psoriasis
Xuejun Zhang, Jun Wang and colleagues report the application of exome sequencing to a large collection of psoriasis cases and controls. They identify seven common and low-frequency nonsynonymous variants withi...
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Article
Trend of Santonian (Late Cretaceous) atmospheric CO2 and global mean land surface temperature: Evidence from plant fossils
Quantitative reconstructions of atmospheric CO2 by using terrestrial and marine records are critical for understanding the so-called “greenhouse” conditions in the Cretaceous, but data from terrestrial plants for...
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Article
The association of the BLK gene with SLE was replicated in Chinese Han
Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors. Recently, single nucleotide polymorphisms (SNPs) in the region of B lymphoid tyrosine kinase (BLK) h...
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Article
Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC
Youwen Zhou and Xue-Jun Zhang and colleagues report a genome-wide association study of generalized vitiligo, a common autoimmune disorder characterized by loss of melanocytes and depigmentation. The authors id...
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Article
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus
Xuejun Zhang and colleagues report results of a genome-wide association study of systemic lupus erythematosus (SLE) in a Chinese Han population. Their work identifies nine new SLE susceptibility loci and revea...
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Article
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21
Xuejun Zhang and colleagues report a genome-wide association and replication studies for psoriasis, conducted in Chinese populations. They confirm previous associations in MHC and IL12B to psoriasis susceptibilit...
