Abstract
Smoking, alcohol consumption and higher body mass index (BMI) are well established risk factors for psoriasis and also associated with the clinical traits of the disease. And the genetic influences on these three risk factors indeed exist. Previously studies have demonstrated these risk factors related genetic variants may also play a role in the development of risk factors-related diseases. Then we performed a hospital-based study in order to evaluate the combined effect of the risk factors and their related polymorphism rs6265 in brain-derived neurotrophic factor (BDNF) gene on psoriasis vulgaris (PV) risk and clinic traits. The case–control study involved 660 subjects including 345 cases and 315 controls in Chinese Han population. The variant of rs6265 was typed by SNaPshot Multiplex Kit (Applied Biosystems Co., USA). We confirmed that higher BMI (≥25), smoking and alcohol consumption were risk factors for PV, and the estimated ORs were 1.63(95 % confidence interval (CI); 1.12–2.37), 2.09(95 % CI; 1.44–3.03) and 1.65(95 % CI; 1.15–2.37) respectively. Genotype and allele distributions did not differ significantly between case and control. However, we found combined effect of rs6265 genotype (GG) and higher BMI (≥25) increased risk of PV (OR = 2.09; 95 % CI, 1.02–4.28; P < 0.05; adjusted OR = 3.19; 95 % CI, 1.37–7.45; P < 0.05) and clinically severity of PV (OR = 2.71; 95 % CI, 1.09–6.72; P < 0.05; adjusted OR = 1.25; 95 % CI, 1.10–1.40; P < 0.05). But none such significant combined effect was observed between others genotype (AA and AG) and other risk factors. In conclusions, the combined effect of BDNF rs6265 genotype (GG) and higher BMI may increases the risk and clinical severity of PV in Chinese Han population.
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Acknowledgments
We are most grateful to the members of all the families who have so willingly participated in this study. This work was supported by grants from Postdoctoral Science Foundation of China (2012M521580); Foundation for Distinguished Young Talents in Higher Education of Guangdong Province (2012LYM_0070); Guangdong Provincial Medical Research Fund (B2012282);The China Natural Science Foundation (81301351, 81101186); The Natural Science Foundation of Guangdong Province (S2013040012415).
Funding
This work was supported by grants from Postdoctoral Science Foundation of China (2012M521580); Foundation for Distinguished Young Talents in Higher Education of Guangdong Province (2012LYM_0070); Guangdong Provincial Medical Research Fund (B2012282);The China Natural Science Foundation (81301351, 81101186); The Natural Science Foundation of Guangdong Province (S2013040012415).
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The data is an original data, has not been published before and is not being considered for publication elsewhere. The authors state no conflict of interest.
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Cheng Quan and Kun-Ju Zhu contributed equally to this work.
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Quan, C., Zhu, KJ., Zhang, C. et al. Combined effects of the BDNF rs6265 (Val66Met) polymorphism and environment risk factors on psoriasis vulgaris. Mol Biol Rep 41, 7015–7022 (2014). https://doi.org/10.1007/s11033-014-3589-4
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DOI: https://doi.org/10.1007/s11033-014-3589-4