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  1. No Access

    Article

    Non-invasive combined surrogates of remifentanil blood concentrations with relevance to analgesia

    Surrogates may provide easy and quick access to information about pharmacological parameters of interest that can be directly measured only with difficulty. Surrogates have been proposed for opioid blood conce...

    Jörn Lötsch, Carsten Skarke, Jutta Darimont… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2013)

  2. No Access

    Article

    Rapid genoty** for relevant CYP1A2 alleles by pyrosequencing

    To develop a rapid and reliable screening method for identifying the relevant cytochrome P450 (CYP) 1A2 alleles CYP1A2*1D (−2467Tdel), *1F (−163A>C), and *1K (−739T>G, −729C>T, −163A>C) that are in linkage disequ...

    Carsten Skarke, Anja Kirchhof… in European Journal of Clinical Pharmacology (2005)

  3. No Access

    Article

    Genetic Predictors of the Clinical Response to Opioid Analgesics

    This review uses a candidate gene approach to identify possible pharmacogenetic modulators of opioid therapy, and discusses these modulators together with demonstrated genetic causes for the variability in cli...

    Dr Jörn Lötsch, Carsten Skarke, Jürgen Liefhold… in Clinical Pharmacokinetics (2004)

  4. No Access

    Article

    Drug Interactions with Patient-Controlled Analgesia

    Patient-controlled analgesia (PCA) has become standard procedure in the clinical treatment of pain. Its widespread use in patients with all kinds of diseases opens a variety of possible interactions between an...

    Jörn Lötsch, Carsten Skarke, Irmgard Tegeder, Gerd Geisslinger in Clinical Pharmacokinetics (2002)