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Article
Open AccessMachine learning identifies right index finger tenderness as key signal of DAS28-CRP based psoriatic arthritis activity
Psoriatic arthritis (PsA) is a chronic inflammatory systemic disease whose activity is often assessed using the Disease Activity Score 28 (DAS28-CRP). The present study was designed to investigate the signific...
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Article
Open AccessRepetitive and compulsive behavior after Early-Life-Pain associated with reduced long-chain sphingolipid species
Pain in early life may impact on development and risk of chronic pain. We developed an optogenetic Cre/loxP mouse model of “early-life-pain” (ELP) using mice with transgenic expression of channelrhodopsin-2 (C...
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Article
Open AccessSAFit2 ameliorates paclitaxel-induced neuropathic pain by reducing spinal gliosis and elevating pro-resolving lipid mediators
Chemotherapy-induced neuropathic pain (CIPN) describes a pathological pain state that occurs dose-dependently as a side effect and can limit or even impede an effective cancer therapy. Unfortunately, current t...
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Article
Open AccessSAFit2 reduces neuroinflammation and ameliorates nerve injury-induced neuropathic pain
Neuropathic pain is experienced worldwide by patients suffering from nerve injuries, infectious or metabolic diseases or chemotherapy. However, the treatment options are still limited because of low efficacy a...
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Article
Open AccessDrug Repurposing to Target Neuroinflammation and Sensory Neuron-Dependent Pain
Around 20% of the American population have chronic pain and estimates in other Western countries report similar numbers. This represents a major challenge for global health care systems. Additional problems fo...
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Article
Open AccessIncreased glucosylceramide production leads to decreased cell energy metabolism and lowered tumor marker expression in non-cancerous liver cells
Hepatocellular carcinoma (HCC) is one of the most difficult cancer types to treat. Liver cancer is often diagnosed at late stages and therapeutic treatment is frequently accompanied by development of multidrug...
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Article
Open AccessDifferences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells
SAMHD1 mediates resistance to anti-cancer nucleoside analogues, including cytarabine, decitabine, and nelarabine that are commonly used for the treatment of leukaemia, through cleavage of their triphosphorylat...
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Article
Open AccessSapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice
Depletion of the enzyme cofactor, tetrahydrobiopterin (BH4), in T-cells was shown to prevent their proliferation upon receptor stimulation in models of allergic inflammation in mice, suggesting that BH4 drives...
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Article
Open AccessA method for the rational selection of drug repurposing candidates from multimodal knowledge harmonization
The SARS-CoV-2 pandemic has challenged researchers at a global scale. The scientific community’s massive response has resulted in a flood of experiments, analyses, hypotheses, and publications, especially in t...
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Open AccessA SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection
SARS-CoV-2 is a novel coronavirus responsible for the COVID-19 pandemic, in which acute respiratory infections are associated with high socio-economic burden. We applied high-content screening to a well-define...
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Article
Open AccessInhibition of mPGES-1 attenuates efficient resolution of acute inflammation by enhancing CX3CL1 expression
Despite the progress to understand inflammatory reactions, mechanisms causing their resolution remain poorly understood. Prostanoids, especially prostaglandin E2 (PGE2), are well-characterized mediators of inflam...
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Article
Open AccessThe immunomodulatory potential of the arylmethylaminosteroid sc1o
Develo** resistance mechanisms of pathogens against established and frequently used drugs are a growing global health problem. Besides the development of novel drug candidates per se, new approaches to count...
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Article
Correction: Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders
Following the publication of this article the authors noted that Torfi Sigurdsson’s name was misspelled. Instead of Sigrudsson it should be Sigurdsson. The PDF and HTML versions of the paper have been modified...
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Article
Open AccessUGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells
The only enzyme in the glycosphingolipid (GSL) metabolic pathway, which produces glucosylceramide (GlcCer) de novo is UDP-glucose ceramide glucosyltransferase (UGCG). UGCG is linked to pro-cancerous processes suc...
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Article
Open AccessIn-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o
Parasite-mediated diseases like malaria and schistosomiasis are growing health problems worldwide and novel drug candidates are urgently needed. In this study, the in-vitro safety profile of steroid compound 1o (...
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Article
Open AccessThe endocannabinoid anandamide has an anti-inflammatory effect on CCL2 expression in vascular smooth muscle cells
Endocannabinoids are important lipid-signaling mediators. Both protective and deleterious effects of endocannabinoids in the cardiovascular system have been reported but the mechanistic basis for these contrad...
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Article
Open AccessUGCG influences glutamine metabolism of breast cancer cells
UDP-glucose ceramide glucosyltransferase (UGCG) is the key enzyme in glycosphingolipid (GSL) metabolism by being the only enzyme that generates glucosylceramide (GlcCer) de novo. Increased UGCG synthesis is assoc...
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Article
Open AccessSelective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML
Hypomethylating agents decitabine and azacytidine are regarded as interchangeable in the treatment of acute myeloid leukemia (AML). However, their mechanisms of action remain incompletely understood, and predi...
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Article
Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase
A role of sphingolipids for inflammatory bowel disease and cancer is evident. However, the relative and separate contribution of sphingolipid deterioration in inflammation versus carcinogenesis for the pathoph...
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Article
Open AccessRole of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes
Ceramides are sphingolipids with defined acyl chain lengths, which are produced by corresponding ceramide synthases (CerS1-6). In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sc...
