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Article
Drug Interactions with Patient-Controlled Analgesia
Patient-controlled analgesia (PCA) has become standard procedure in the clinical treatment of pain. Its widespread use in patients with all kinds of diseases opens a variety of possible interactions between an...
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Article
Genetic Predictors of the Clinical Response to Opioid Analgesics
This review uses a candidate gene approach to identify possible pharmacogenetic modulators of opioid therapy, and discusses these modulators together with demonstrated genetic causes for the variability in cli...
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Article
Rapid genoty** for relevant CYP1A2 alleles by pyrosequencing
To develop a rapid and reliable screening method for identifying the relevant cytochrome P450 (CYP) 1A2 alleles CYP1A2*1D (−2467Tdel), *1F (−163A>C), and *1K (−739T>G, −729C>T, −163A>C) that are in linkage disequ...
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Article
Non-invasive combined surrogates of remifentanil blood concentrations with relevance to analgesia
Surrogates may provide easy and quick access to information about pharmacological parameters of interest that can be directly measured only with difficulty. Surrogates have been proposed for opioid blood conce...