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Article
Open AccessStriatonigral neurons divide into two distinct morphological-physiological phenotypes after chronic L-DOPA treatment in parkinsonian rats
Dendritic regression of striatal spiny projection neurons (SPNs) is a pathological hallmark of Parkinson’s disease (PD). Here we investigate how chronic dopamine denervation and dopamine replacement with L-DOP...
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Article
Electroporation-mediated gene transfer directly to the swine heart
In vivo gene transfer to the ischemic heart via electroporation holds promise as a potential therapeutic approach for the treatment of heart disease. In the current study, we investigated the use of in vivo elect...
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Article
Efficient transduction of neurons using Ross River glycoprotein-pseudotyped lentiviral vectors
Lentiviral vectors are promising tools for CNS gene transfer since they efficiently transduce the cells of the nervous system in vivo. In this study, we have investigated the transduction efficiency of lentiviral...
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Article
Stable, long-term label opens doors for gene therapy
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Article
Evaluation of Tet-on system to avoid transgene down-regulation in ex vivo gene transfer to the CNS
Ex vivo gene transfer to the CNS has so far been hampered by instability of transgene expression. To avoid the phenomenon of transgene down-regulation, we have employed strong, constitutive promoters and compa...
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Chapter
Casuarina-Frankia Symbioses - Molecular Studies of Frankia
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Chapter and Conference Paper
Use of Conditionally Immortalized Neural Progenitors for Transplantation and Gene Transfer to the CNS
Cell transplantation offers interesting possiblities for gene transfer to the CNS in that the cells can be genetically modified prior to grafting and thus used as carriers for transgenes that endow the grafted...
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Chapter and Conference Paper
Gene Therapy in Animal Models of Neurological Disorders
The relative importance of synaptic versus paracrine dopamine release for the expression of functional effects following intrastriatal grafting has not, been established. In the present study, we grafted cell ...
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Article
Hemorrhagic shock in the dog
Oxygen consumption, hemodynamics, and regional blood flow (with the radioactive microspheres technique) were determined in 12 anesthetized dogs subjected to hemorrhagic shock. The animals were kept in hypotens...
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Article
Bacteria and inflammatory cells in maxillary sinusitis
A series of maxillary sinus mucosal specimens and a series of smears of retained maxillary sinus secretions were studied with regard to the relationship between bacteria and inflammatory cells in order to illu...
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Article
Effect of phenoxymethylpenicillin, erythromycin, lymecycline and doxycycline upon the release of proteases from human leukocytes
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Article
DDT and the frequency of implanted ova in the mouse