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    Evaluation of Tet-on system to avoid transgene down-regulation in ex vivo gene transfer to the CNS

    Ex vivo gene transfer to the CNS has so far been hampered by instability of transgene expression. To avoid the phenomenon of transgene down-regulation, we have employed strong, constitutive promoters and compa...

    J Johansen, C Rosenblad, K Andsberg, A Møller, C Lundberg, A Björlund… in Gene Therapy (2002)