62 Result(s)

Article

The impact of parent history of severe mental illness on schizophrenia outcomes: results from the real-world FACE-SZ cohort

Parent history of severe mental illness (PHSMI) may have long-term consequences in adult offspring due to genetic and early environmental factors in preliminary studies. To compare the outcomes associated in s...

A. Garosi, P. L. Sunhary de Verville… in European Archives of Psychiatry and Clinic… (2023)

Article

Early-life factors associated with increased risk of disability pension in the national real-world schizophrenia FACE-SZ cohort study

Among severe psychiatric disorders, schizophrenia has one of the highest impacts on professional and personal functioning with important indirect costs including disability pension allowance for the patients w...

G. Fond, J. Dubreucq… in European Archives of Psychiatry and Clinic… (2022)

Article

Chronic low-grade peripheral inflammation is associated with ultra resistant schizophrenia. Results from the FACE-SZ cohort

A high rate of patients with schizophrenia (SZ) does not sufficiently respond to antipsychotic medication, which is associated with relapses and poor outcomes. Chronic peripheral inflammation has been repeated...

G. Fond, O. Godin, L. Boyer, F. Berna… in European Archives of Psychiatry and Clinic… (2019)

Article

Towards an improved access to psychiatric rehabilitation: availability and effectiveness at 1-year follow-up of psychoeducation, cognitive remediation therapy, cognitive behaviour therapy and social skills training in the FondaMental Advanced Centers of Expertise-Schizophrenia (FACE-SZ) national cohort

Psychosocial Interventions (PIs) have shown positive effects on clinical and functional outcomes of schizophrenia (SZ) in randomized controlled trials. However their effectiveness and accessibility remain uncl...

Julien Dubreucq, B. Ycart, F. Gabayet… in European Archives of Psychiatry and Clinic… (2019)

Article

Tobacco smoking is associated with antipsychotic medication, physical aggressiveness, and alcohol use disorder in schizophrenia: results from the FACE-SZ national cohort

Tobacco smoking is common in schizophrenia and is one of the main causes of premature mortality in this disorder. Little is known about clinical correlates and treatments associated with tobacco smoking in pat...

J. Mallet, Y. Le Strat, F. Schürhoff… in European Archives of Psychiatry and Clinic… (2019)

Article

Relationships between low-grade peripheral inflammation and psychotropic drugs in schizophrenia: results from the national FACE-SZ cohort

Low-grade inflammation has repeatedly been associated with schizophrenia (SZ) and in particular with cognitive impairment. Female gender, overweight and tobacco smoking have been suggested as risk factors to i...

G. Fond, N. Resseguier, F. Schürhoff… in European Archives of Psychiatry and Clinic… (2018)

Article

Benzodiazepine long-term administration is associated with impaired attention/working memory in schizophrenia: results from the national multicentre FACE-SZ data set

The effect of benzodiazepine long-term administration (BLTA) in cognitive functioning of subjects with schizophrenia (SZ) has been partially explored to date. The objective was to assess BLTA-associated cognit...

Guillaume Fond, F. Berna, L. Boyer, O. Godin… in European Archives of Psychiatry and Clinic… (2018)

Article

Chronic low-grade peripheral inflammation is associated with severe nicotine dependence in schizophrenia: results from the national multicentric FACE-SZ cohort

Chronic peripheral inflammation (CPI) has been associated with cognitive impairment in schizophrenia (SZ). However, its sources remain unclear, more specifically it is not known whether tobacco smoking is a so...

G. Fond, F. Berna, M. Andrianarisoa… in European Archives of Psychiatry and Clinic… (2017)

Article

Le corps de l’enfant aux prises avec le cancer

La maladie provoque chez l’enfant un bouleversement identitaire et, de fait, une transformation subjective le faisant passer de la position de « sujet » désirant et en possession d’un savoir (comme il peut l’ê...

J. Mallet, P. Martin-Mattera, A. Levy, P. Peretti, M.-A. Roquand… in Psycho-Oncologie (2017)

Article

Local inactivation of Gpr88 in the nucleus accumbens attenuates behavioral deficits elicited by the neonatal administration of phencyclidine in rats

Gpr88, an orphan G-protein-coupled receptor, is highly and almost exclusively expressed in the medium spiny projection neurons of the striatum, and may thus participate in the control of motor functions and co...

M Ingallinesi, L Le Bouil, N Faucon Biguet, A Do Thi… in Molecular Psychiatry (2015)

Article

Endospanin 1 silencing in the hypothalamic arcuate nucleus contributes to sustained weight loss of high fat diet obese mice

Leptin targets specific receptors (OB-R) expressed in the hypothalamus to regulate energy balance. Leptin decreases food intake in normal weight individuals, but this effect is blunted in obese subjects who ar...

V Vauthier, T D Swartz, P Chen, C Roujeau, M Pagnon, J Mallet, C Sarkis… in Gene Therapy (2014)

Article

Analyse et impact des revues de morbimortalité (RMM) au sein d’un pôle de médecine d’urgence

Une revue de morbimortalité (RMM) a pour objectif l’analyse collective rétrospective de cas anonymisés marqués par la survenue d’un décès ou d’une complication, afin d’améliorer la qualité des soins. Notre obj...

B. Vallé, E. Dehours, J. Mallet, M. Belhadj… in Annales françaises de médecine d'urgence (2012)

Article

Donner un sens à son cancer, « ça m’avance à quoi ? »

J. Mallet in Psycho-Oncologie (2009)

Article

Meta-analysis of 32 genome-wide linkage studies of schizophrenia

A genome scan meta-a nalysis (GSMA) was carried out on 32 independent genome-wide linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases affected with schizophrenia (SCZ) or related disor...

M Y M Ng, D F Levinson, S V Faraone, B K Suarez, L E DeLisi… in Molecular Psychiatry (2009)

Article

Genomewide linkage scan of schizophrenia in a large multicenter pedigree sample using single nucleotide polymorphisms

A genomewide linkage scan was carried out in eight clinical samples of informative schizophrenia families. After all quality control checks, the analysis of 707 European-ancestry families included 1615 affecte...

P A Holmans, B Riley, A E Pulver, M J Owen, D B Wildenauer… in Molecular Psychiatry (2009)

Article

The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4

HIPK2 is a eukaryotic Serine–Threonine kinase that controls cellular proliferation and survival in response to exogenous signals. Here, we show that the human transcription factor ZBTB4 is a new target of HIPK...

D Yamada, R Pérez-Torrado, G Filion, M Caly, B Jammart, V Devignot, N Sasai… in Oncogene (2009)

Article

Does neuronal expression of GDNF effectively protect dopaminergic neurons in a rat model of Parkinson's disease?

The transfer of the Glial cell line-derived neurotrophic factor (GDNF) gene to the central nervous system by a recombinant adenoviral vector (Ad) was studied. We constructed the adenovirus vector Ad-NSE-GDNF f...

N A Do Thi, P Saillour, L Ferrero, T Paunio, J Mallet in Gene Therapy (2007)