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Article
Open AccessHuman retinal endothelial cells express functional interleukin-6 receptor
Interleukin (IL)-6 is an inflammatory cytokine present in the eye during non-infectious uveitis, where it contributes to the progression of inflammation. There are two major IL-6 signaling pathways: classic si...
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Article
Open AccessExpression of microRNA in human retinal pigment epithelial cells following infection with Zaire ebolavirus
Survivors of Ebola virus disease (EVD) are at risk of develo** blinding intraocular inflammation—or uveitis—which is associated with retinal pigment epithelial (RPE) scarring and persistence of live Zaire ebola...
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Article
Open AccessICAM-1-related long non-coding RNA: promoter analysis and expression in human retinal endothelial cells
Regulation of intercellular adhesion molecule (ICAM)-1 in retinal endothelial cells is a promising druggable target for retinal vascular diseases. The ICAM-1-related (ICR) long non-coding RNA stabilizes ICAM-1...
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Article
Genome-wide association study for sight-threatening diabetic retinopathy reveals association with genetic variation near the GRB2 gene
Diabetic retinopathy is a serious complication of diabetes mellitus and can lead to blindness. A genetic component, in addition to traditional risk factors, has been well described although strong genetic fact...
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Article
CD44 isoforms in human retinal and choroidal endothelial cells
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Article
Open AccessPrediction of cis-regulatory elements controlling genes differentially expressed by retinal and choroidal vascular endothelial cells
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Article
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3
Clinical trials of small interfering RNA (siRNA) targeting vascular endothelial growth factor-A (VEGFA) or its receptor VEGFR1 (also called FLT1), in patients with blinding choroidal neovascularization (CNV) from...
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Article
Open AccessPrediction of cis-regulatory elements controlling genes differentially expressed by retinal and choroidal vascular endothelial cells
Cultured endothelial cells of the human retina and choroid demonstrate distinct patterns of gene expression. We hypothesized that differential gene expression reflected differences in the interactions of trans...
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Article
A Novel H572R Mutation in the Transforming Growth Factor-β-Induced Gene in a Thai Family with Lattice Corneal Dystrophy Type I
To describe a large Thai family with lattice corneal dystrophy (LCD) type I and to determine whether this LCD is associated with mutations within the transforming growth factor-β-induced (TGFBI) gene.
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Protocol
Retinal Tissue
Mutations within genes that are specifically expressed within the retina and/or the retinal pigment epithelium (RPE) are associated with the majority of inherited retinal degenerations (1). Retinal degenerative d...
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Protocol
Corneal Cells
A mammalian cornea can be maintained in vitro for days (1,2), allowing ex vivo transduction of this tissue prior to transplantation (3,4). Ex vivo transduction of the cornea is useful for studying the efficacy of...
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Article
Isolation and characterization of the human homeobox gene HOX D1
Homeobox genes, first identified in Drosophila, encode transcription factors that regulate embryonic development along the anteroposterior axis of an organism. Vertebrate homeobox genes are described on the basis...
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Article
Heterozygous loss of Six5 in mice is sufficient to cause ocular cataracts
Myotonic dystrophy (DM) is an autosomal dominant disorder characterized by skeletal muscle wasting, myotonia, cardiac arrhythmia, hyperinsulinaemia, mental retardation and ocular cataracts1. The genetic defect in...
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Article
Localisation of the human blue cone pigment gene to chromosome band 7q31.3-32
Blue cone pigment (BCP) is one of three types of cone photoreceptors responsible for normal colour vision. In this study, the BCP gene has been localised to chromosome 7q31.3-32 by fluorescent in situ hybridis...