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  1. No Access

    Chapter and Conference Paper

    Therapeutic Approaches to Histone Reprogramming in Retinal Degeneration

    Recent data have revealed epigenetic derangements and subsequent chromatin remodeling as a potent biologic switch for chronic inflammation and cell survival which are important therapeutic targets in the patho...

    Andre K. Berner, Mark E. Kleinman in Retinal Degenerative Diseases (2016)

  2. Article

    The Immune System and AMD

    Age-related macular degeneration is a complex, multifactorial disease that has yet to be completely understood. Significant efforts in the basic and clinical sciences have unveiled numerous areas that appear t...

    Paul A. Frederick, Mark E. Kleinman in Current Ophthalmology Reports (2014)

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  3. No Access

    Chapter and Conference Paper

    A Window to Innate Neuroimmunity: Toll-Like Receptor-Mediated Cell Responses in the Retina

    The retina and its supporting cellular architecture are a valuable biologic system to study neurocytotoxic responses that may reveal important pathways in both retinal and neural degenerative diseases. The inn...

    Mark E. Kleinman, Jayakrishna Ambati in Retinal Degenerative Diseases (2012)

  4. No Access

    Article

    DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

    Geographic atrophy (GA), an untreatable advanced form of age-related macular degeneration, results from retinal pigmented epithelium (RPE) cell degeneration. Here we show that the microRNA (miRNA)-processing e...

    Hiroki Kaneko, Sami Dridi, Valeria Tarallo, Bradley D. Gelfand… in Nature (2011)

  5. No Access

    Article

    Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth

    Although endogenous inhibitors of blood vessel growth have been studied extensively, specific inhibitors of lymphatic vessel growth have not been identified. Albuquerque et al. now identify truncated, secreted ve...

    Romulo J C Albuquerque, Takahiko Hayashi, Won Gil Cho, Mark E Kleinman… in Nature Medicine (2009)

  6. No Access

    Article

    CCR3 is a target for age-related macular degeneration diagnosis and therapy

    Age-related macular degeneration (AMD), a leading cause of blindness worldwide, is as prevalent as cancer in industrialized nations. Most blindness in AMD results from invasion of the retina by choroidal neova...

    Atsunobu Takeda, Judit Z. Baffi, Mark E. Kleinman, Won Gil Cho, Miho Nozaki… in Nature (2009)

  7. No Access

    Article

    Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

    Clinical trials of small interfering RNA (siRNA) targeting vascular endothelial growth factor-A (VEGFA) or its receptor VEGFR1 (also called FLT1), in patients with blinding choroidal neovascularization (CNV) from...

    Mark E. Kleinman, Kiyoshi Yamada, Atsunobu Takeda, Vasu Chandrasekaran… in Nature (2008)

  8. No Access

    Article

    Corneal avascularity is due to soluble VEGF receptor-1

    The cornea is one of the few tissues in the body with no blood vessels flowing through it. This blood-vessel-free island is often used to test anti-angiogenic therapies for cancer, arthritis, atherosclerosis, ...

    Balamurali K. Ambati, Miho Nozaki, Nirbhai Singh, Atsunobu Takeda, Pooja D. Jani… in Nature (2006)

  9. No Access

    Article

    Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

    The trafficking of circulating stem and progenitor cells to areas of tissue damage is poorly understood. The chemokine stromal cell–derived factor-1 (SDF-1 or CXCL12) mediates homing of stem cells to bone marr...

    Daniel J Ceradini, Anita R Kulkarni, Matthew J Callaghan, Oren M Tepper… in Nature Medicine (2004)