Proceedings of the Pacific Rim Statistical Conference for Production Engineering
Big Data, Production Engineering and Statistics
Page
%P
-
Article
A mixed methods study to uncover impediments to accurate diagnosis of nonradiographic axial spondyloarthritis in the USA
Delayed diagnosis of axial spondyloarthritis (axSpA) is well documented; little is known about the diagnostic journey and impediments for US patients with nonradiographic axSpA (nr-axSpA). It is hypothesized t...
-
Article
Open AccessHLA-B27 is associated with reduced disease activity in axial spondyloarthritis
HLA-B27 is associated with increased susceptibility and disease activity of ankylosing spondylitis, but the effect of HLA-B27 on the activity of the broader category now called axial spondyloarthritis (AxSpA) ...
-
Article
Tofacitinib as a Steroid-Sparing Therapy in Pulmonary Sarcoidosis, an Open-Label Prospective Proof-of-Concept Study
This is a prospective, open-label, proof-of-concept study of tofacitinib, a Janus kinase inhibitor, as a steroid-sparing therapy in corticosteroid-dependent pulmonary sarcoidosis. Five patients with corticoste...
-
Article
Assessing rheumatologists’ attitudes and utilization of classification criteria for ankylosing spondylitis and axial spondyloarthritis: a global effort
This study aims to assess rheumatologists’ perceptions, utilization patterns, and attitudes towards the modified New York (mNY) criteria for ankylosing spondylitis (AS) and Assessment of SpondyloArthritis Inte...
-
Article
Open AccessRadiologic imaging shows variable accuracy in diagnosing orbital inflammatory disease and assessing its activity
Radiologic orbital imaging provides important information in the diagnosis and management of orbital inflammation. However, the diagnostic value of orbital imaging is not well elucidated. This study aimed to i...
-
Article
Open AccessRNA-Seq of human whole blood: Evaluation of globin RNA depletion on Ribo-Zero library method
Peripheral blood is a highly accessible biofluid providing a rich source of information about human physiology and health status. However, for studies of the blood transcriptome with RNA sequencing (RNA-Seq) t...
-
Article
Open AccessMass spectrometry quantitation of proteins from small pools of develo** auditory and vestibular cells
Hair cells of the inner ear undergo postnatal development that leads to formation of their sensory organelles, synaptic machinery, and in the case of cochlear outer hair cells, their electromotile mechanism. T...
-
Book and Conference Proceedings
-
Protocol
Utilizing RNA-Seq to Identify Differentially Expressed Genes in Glaucoma Model Tissues, Such as the Rodent Optic Nerve Head
Understanding the cellular pathways activated by elevated intraocular pressure (IOP) is crucial for the development of more effective glaucoma treatments. Microarray studies have previously been used to identi...
-
Article
Open AccessCorrection: Corrigendum: Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like
Nature Communications 7 Article number: 10833 (2016). Published 1 March 2016; Updated 14 August 2017 Technical support for this Article was not fully acknowledged. The Acknowledgements should have included the...
-
Article
Open AccessAnnexin A5 is the Most Abundant Membrane-Associated Protein in Stereocilia but is Dispensable for Hair-Bundle Development and Function
The phospholipid- and Ca2+-binding protein annexin A5 (ANXA5) is the most abundant membrane-associated protein of ~P23 mouse vestibular hair bundles, the inner ear’s sensory organelle. Using quantitative mass spe...
-
Article
Open AccessStereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like
Hair cells tightly control the dimensions of their stereocilia, which are actin-rich protrusions with graded heights that mediate mechanotransduction in the inner ear. Two members of the myosin-III family, MYO...
-
Article
Open AccessHair-bundle proteomes of avian and mammalian inner-ear utricles
Examination of multiple proteomics datasets within or between species increases the reliability of protein identification. We report here proteomes of inner-ear hair bundles from three species (chick, mouse, a...
-
Article
Open AccessThe proteome of mouse vestibular hair bundles over development
Development of the vertebrate hair bundle is a precisely orchestrated event that culminates in production of a tightly ordered arrangement of actin-rich stereocilia and a single axonemal kinocilium. To underst...
-
Article
Risk factors for retinopathy of prematurity: insights from outlier infants
To investigate the characteristics of outlier infants for insights into ROP risk.
-
Article
Molecular architecture of the chick vestibular hair bundle
In this Resource study, the authors used high-resolution mass spectrometry to elucidate the precise proteomic complement of the inner ear hair bundle. Many of the proteins that are enriched in the hair bundles...
-
Article
Open AccessLong-term follow-up of patients treated with multiple fluocinolone acetonide implants for noninfectious uveitis
To evaluate long-term outcomes in eyes undergoing exchange of fluocinolone acetonide intravitreal implants for noninfectious uveitis.
-
Article
Open AccessTreatment length and outcomes among adolescents: a secondary data analysis
Adaptations to evidence-based substance abuse treatment programs may impact their effectiveness. A qualitative study of MET/CBT-5 implementation in community agencies treating adolescents found that the majori...
-
Article
Methamphetamine Causes Persistent Immune Dysregulation: A Cross-Species, Translational Report
Methamphetamine (MA) dependence causes serious cognitive impairments that can persist during abstinence and negatively affect recovery outcomes. Evidence suggests that immune factors, such as cytokines, chemok...
-
Article
Reducing HIV-Related Risk Behaviors Among Injection Drug Users in Residential Detoxification
This study of 632 drug injectors enrolled in eight residential detoxification centers within the National Drug Abuse Treatment Clinical Trials Network tested three interventions to reduce drug and sex risk beh...
