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Article
Open AccessTargeting lysine demethylase 5 (KDM5) in mantle cell lymphoma
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Article
Open AccessIntegrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes
Acute myeloid leukaemia (AML) patients harbouring certain chromosome abnormalities have particularly adverse prognosis. For these patients, targeted therapies have not yet made a significant clinical impact. T...
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Chapter
Molekulargenetik bei indolenten Lymphomen
Das genetische Bild der indolenten Lymphome hat sich im Zuge der Einführung neuer Technologien erheblich weiterentwickelt, da wir nun in der Lage sind, die genetischen Merkmale dieser Tumoren zu dokumentieren ...
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Article
Open AccessAcquired somatic variants in inherited myeloid malignancies
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Open AccessAuthor Correction: Genome-wide association study identifies susceptibility loci for acute myeloid leukemia
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Article
Open AccessGenome-wide association study identifies susceptibility loci for acute myeloid leukemia
Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorp...
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Article
Open AccessDrug ranking using machine learning systematically predicts the efficacy of anti-cancer drugs
Artificial intelligence and machine learning (ML) promise to transform cancer therapies by accurately predicting the most appropriate therapies to treat individual patients. Here, we present an approach, named...
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Chapter
Molecular Genetics in Indolent Lymphomas
The genetic portrait of indolent lymphomas has evolved considerably as the implementation of new technologies has shaped our ability to document the genetic features of these tumors, revealing what defines the...
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Protocol
Generation and Surgical Analysis of Genetic Mouse Models to Study NF-κB-Driven Pathogenesis of Diffuse Large B Cell Lymphoma
Enforced activation of NF-κB signaling can be achieved by constitutive NF-κB-inducing kinases, IKK2 and NIK, or via lymphoma-associated mutants of MYD88, CARD11, and CD79B. In order to model Diffuse Large B Ce...
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Article
Open AccessDistinct genetic changes reveal evolutionary history and heterogeneous molecular grade of DLBCL with MYC/BCL2 double-hit
Using a Burkitt lymphoma-like gene expression signature, we recently defined a high-risk molecular high-grade (MHG) group mainly within germinal centre B-cell like diffuse large B-cell lymphomas (GCB-DLBCL), w...
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Article
Open AccessThe complex genetic landscape of familial MDS and AML reveals pathogenic germline variants
The inclusion of familial myeloid malignancies as a separate disease entity in the revised WHO classification has renewed efforts to improve the recognition and management of this group of at risk individuals....
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Article
Follicular lymphoma
Follicular lymphoma (FL) is a systemic neoplasm of the lymphoid tissue displaying germinal centre (GC) B cell differentiation. FL represents ~5% of all haematological neoplasms and ~20–25% of all new non-Hodgk...
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Article
Oncogenic Rag GTPase signalling enhances B cell activation and drives follicular lymphoma sensitive to pharmacological inhibition of mTOR
The humoral immune response requires that B cells undergo a sudden anabolic shift and high cellular nutrient levels, which are required to sustain the subsequent proliferative burst. Follicular lymphoma (FL) o...
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Article
Correction: Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma
In the original version of this article the authors noted an omission in the author affiliations where the university details: Queen Mary University of London was not included in the original affiliation for t...
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Open AccessGATA2 monoallelic expression underlies reduced penetrance in inherited GATA2-mutated MDS/AML
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Article
Open AccessProteomic and genomic integration identifies kinase and differentiation determinants of kinase inhibitor sensitivity in leukemia cells
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Open AccessGenomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma
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Article
Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors
Loss-of-function mutations of cyclic-AMP response element binding protein, binding protein (CREBBP) are prevalent in lymphoid malignancies. However, the tumour suppressor functions of CREBBP remain unclear. We...
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Article
Correction: Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
Nat. Genet.; 10.1038/ng.3473; corrected online 12 January 2016 In the version of this article initially published online, several funding sources were omitted from the Acknowledgments section. The error has be...
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Article
Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
Jessica Okosun, David Sabatini and colleagues identify recurrent RRAGC mutations in follicular lymphoma, resulting in activated mTORC1 signaling. The activating nature of the mutations, their existence within the...
