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Article
Factors at the initial visit associated with poor visual outcomes in patients with acute retinal necrosis
Acute retinal necrosis (ARN) is a vision-threatening disease caused by herpesvirus infection. This study aimed to investigate the visual prognostic factors that could be determined at the initial visit.
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Article
Relationships between causative genes and epiretinal membrane formation in Japanese patients with retinitis pigmentosa
To investigate the relationships between macular complications and causative genes frequently found in Japanese patients with retinitis pigmentosa (RP).
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Article
Genotypes and clinical features of RHO-associated retinitis pigmentosa in a Japanese population
To report the genotypes and clinical features of RHO-associated retinitis pigmentosa (RHO-RP) in the Kyushu region of Japan.
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Article
Correction to: Persistence of vascular empty sleeves in choroidal neovascularization after anti-VEGF therapy in both animal models and humans
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Article
Persistence of vascular empty sleeves in choroidal neovascularization after VEGF therapy in both animal models and humans
Choroidal neovascularization (CNV) often recurs during anti-vascular endothelial growth factor (VEGF) therapy; however, little is known about the mechanism of vascular regrowth. Vascular regrowth along the emp...
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Article
Long-term outcomes of infliximab in patients with Behçet's disease-associated uveitis
To evaluate long-term outcomes of infliximab (IFX) treatment in patients with Behçet's disease (BD)-associated uveitis.
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Article
Morphology and fluorescein leakage in diabetic retinal microaneurysms: a study using multiple en face OCT angiography image averaging
To investigate the relevance of microaneurysm morphology in optical coherence tomography angiography (OCTA) image averaging and fluorescein leakage in diabetic retinopathy (DR).
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Article
Increased vitreous levels of B cell activation factor (BAFF) and soluble interleukin-6 receptor in patients with macular edema due to uveitis related to Behçet’s disease and sarcoidosis
Uveitis accounts for 10–15% of all cases of blindness in the developed world. Uveitic macular edema (UME) is a primary cause of permanent visual impairment in patients with uveitis. Because proinflammatory med...
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Article
Postoperative follow-up of submacular hemorrhage displacement treated with vitrectomy and subretinal injection of tissue plasminogen activator: ultrawide-field fundus autofluorescence imaging in gas-filled eyes
To investigate the utility of Optos ultrawide-field fundus autofluorescence (UWF-FAF) imaging for postoperative follow-up of gas-filled eyes after vitrectomy with subretinal tissue-plasminogen activator (t-PA)...
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Article
Open AccessVitreous levels of interleukin-35 as a prognostic factor in B-cell vitreoretinal lymphoma
Vitreoretinal lymphoma (VRL) is a rare disease of B-cell origin with poor prognosis. Regulatory cytokines promote tumor development by suppressing antitumor immunity in several cancer types, including B-cell m...
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Chapter
Acute Retinal Necrosis and Progressive Outer Retinal Necrosis
Necrotizing retinopathies, including acute retinal necrosis (ARN) and progressive outer retinal necrosis (PORN), are a group of uncommon posterior segment complications associated with infections caused by the...
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Article
Risk factors for failure of vitrectomy cell block technique in cytological diagnosis of vitreoretinal lymphoma
To determine the factors that may affect the accuracy of vitrectomy cell block technique in detecting atypical lymphoid cells in patients with vitreoretinal lymphoma (VRL).
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Article
Crucial role of P2X7 receptor for effector T cell activation in experimental autoimmune uveitis
To investigate the roles of P2X7 receptors (P2RX7) in the pathogenesis of experimental autoimmune uveoretinitis (EAU).
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Article
Open AccessErratum: High-Resolution Imaging by Adaptive Optics Scanning Laser Ophthalmoscopy Reveals Two Morphologically Distinct Types of Retinal Hard Exudates
Scientific Reports 6: Article number: 33574; published online: 19 September 2016; updated: 03 November 2016
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Article
Changes in chorioretinal blood flow velocity and cerebral blood flow after carotid endarterectomy
To investigate the changes in chorioretinal blood flow velocity and cerebral blood after carotid endarterectomy (CEA).
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Article
Open AccessHigh-Resolution Imaging by Adaptive Optics Scanning Laser Ophthalmoscopy Reveals Two Morphologically Distinct Types of Retinal Hard Exudates
Histological studies from autopsy specimens have characterized hard exudates as a composition of lipid-laden macrophages or noncellular materials including lipid and proteinaceous substances (hyaline substance...
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Article
Attenuation of EMT in RPE cells and subretinal fibrosis by an RAR-γ agonist
Subretinal fibrosis contributes to the loss of vision associated with age-related macular degeneration (AMD). Retinal pigment epithelial (RPE) cells play a key role in the pathogenesis of AMD including the fib...
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Article
Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth
Although endogenous inhibitors of blood vessel growth have been studied extensively, specific inhibitors of lymphatic vessel growth have not been identified. Albuquerque et al. now identify truncated, secreted ve...
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Article
CCR3 is a target for age-related macular degeneration diagnosis and therapy
Age-related macular degeneration (AMD), a leading cause of blindness worldwide, is as prevalent as cancer in industrialized nations. Most blindness in AMD results from invasion of the retina by choroidal neova...
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Article
Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis
MRL/lpr mice develop a systemic autoimmune disease that is reminiscent of systemic lupus erythematosus (SLE) and Sjögren’s syndrome in humans. To investigate the role of IL-27 in the development of autoimmune dis...
