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  1. No Access

    Article

    Identification of a Putative α-synuclein Radioligand Using an in silico Similarity Search

    Previous studies from our lab utilized an ultra-high throughput screening method to identify compound 1 as a small molecule that binds to alpha-synuclein (α-synuclein) fibrils. The goal of the current study was t...

    Bieneke Janssen, Guilong Tian, Zsofia Lengyel-Zhand… in Molecular Imaging and Biology (2023)

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    Chapter

    PET Imaging of Purinergic Receptors

    Over the recent years, interest in the purinergic signaling system has sparked in the field of positron emission tomography (PET). Purinergic receptors play key roles in physiological and pathological processe...

    Bieneke Janssen, Danielle J. Vugts… in PET and SPECT of Neurobiological Systems (2021)

  3. Article

    Open Access

    The P2X7 receptor tracer [11C]SMW139 as an in vivo marker of neuroinflammation in multiple sclerosis: a first-in man study

    The novel PET tracer [11C]SMW139 binds with high affinity to the P2X7 receptor, which is expressed on pro-inflammatory microglia. The purposes of this first in-man study were to characterise pharmacokinetics of [

    Marloes H. J. Hagens, Sandeep S. V. Golla… in European Journal of Nuclear Medicine and M… (2020)

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    Chapter

    Imaging Histamine Receptors Using PET and SPECT

    The histaminergic system contains four subtypes of G-protein-coupled receptors: H1R, H2R, H3R and H4R. In the central nervous system, they mediate the action of histamine in pituitary hormone secretion, wakefulne...

    Uta Funke, Danielle J. Vugts, Bieneke Janssen… in PET and SPECT of Neurobiological Systems (2014)