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  1. No Access

    Article

    Identification of a Putative α-synuclein Radioligand Using an in silico Similarity Search

    Previous studies from our lab utilized an ultra-high throughput screening method to identify compound 1 as a small molecule that binds to alpha-synuclein (α-synuclein) fibrils. The goal of the current study was t...

    Bieneke Janssen, Guilong Tian, Zsofia Lengyel-Zhand… in Molecular Imaging and Biology (2023)

  2. No Access

    Article

    Evaluation of a Low-Toxicity PARP Inhibitor as a Neuroprotective Agent for Parkinson’s Disease

    Repurposing PARP-1 inhibitors (PARPi) for non-oncological applications offers an attractive therapeutic strategy for pathological conditions characterized by PARP-1 hyperactivity. In the context of Parkinson’s...

    Laura N. Puentes, Zsofia Lengyel-Zhand, Sean W. Reilly… in Molecular Neurobiology (2021)

  3. No Access

    Article

    The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Aβ42 and Its Protein Aggregates

    Our lab has recently shown that the Sigma-2 Receptor/Transmembrane Protein 97 (TMEM97) and Progesterone Receptor Membrane Component 1 (PGRMC1) form a complex with the Low Density Lipoprotein Receptor (LDLR), a...

    Aladdin Riad, Zsofia Lengyel-Zhand, Chenbo Zeng, Chi-Chang Weng… in Molecular Neurobiology (2020)