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PET Imaging of Purinergic Receptors

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PET and SPECT of Neurobiological Systems

Abstract

Over the recent years, interest in the purinergic signaling system has sparked in the field of positron emission tomography (PET). Purinergic receptors play key roles in physiological and pathological processes, although the exact role in these processes is not always fully understood. PET provides an excellent imaging technique to study (patho)physiological processes in the living brain, and therefore radiopharmaceuticals (or tracers) targeting different purinergic receptors have been developed recently. This chapter will discuss the state of the art of PET tracer development for the P2 family of purinergic receptors, which is especially of interest for visualization of neuroinflammation, more specifically microglial activation.

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Authors and Affiliations

  1. Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Bieneke Janssen

  2. Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

    Danielle J. Vugts & Albert D. Windhorst

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  1. Bieneke Janssen
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  2. Danielle J. Vugts
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  3. Albert D. Windhorst
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Correspondence to Bieneke Janssen .

Editor information

Editors and Affiliations

  1. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Rudi A.J.O. Dierckx

  2. Faculty of Electrical Engineering, Medical Engineering and Computer Science, Offenburg University, Offenburg, Germany

    Andreas Otte

  3. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Erik F.J. de Vries

  4. Nuclear Medicine and Molecular Imaging, University Medical Center, Groningen, The Netherlands

    Aren van Waarde

  5. Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers location VUmc, Amsterdam, The Netherlands

    Adriaan A. Lammertsma

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Janssen, B., Vugts, D.J., Windhorst, A.D. (2021). PET Imaging of Purinergic Receptors. In: Dierckx, R.A., Otte, A., de Vries, E.F., van Waarde, A., Lammertsma, A.A. (eds) PET and SPECT of Neurobiological Systems. Springer, Cham. https://doi.org/10.1007/978-3-030-53176-8_24

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