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Article
Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis
In cell models, changes in the ‘accessible’ pool of plasma membrane (PM) cholesterol are linked with the regulation of endoplasmic reticulum sterol synthesis and metabolism by the Aster family of nonvesicular ...
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Article
Open AccessParkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes
Parkin, an E3 ubiquitin ligase, plays an essential role in mitochondrial quality control. However, the mechanisms by which Parkin connects mitochondrial homeostasis with cellular metabolism in adipose tissue r...
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Article
An integrative systems genetic analysis of mammalian lipid metabolism
Dysregulation of lipid homeostasis is a precipitating event in the pathogenesis and progression of hepatosteatosis and metabolic syndrome. These conditions are highly prevalent in developed societies and curre...
