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Article
Circadian control of tumor immunosuppression affects efficacy of immune checkpoint blockade
The circadian clock is a critical regulator of immunity, and this circadian control of immune modulation has an essential function in host defense and tumor immunosurveillance. Here we use a single-cell RNA se...
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Article
Author Correction: Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4
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Article
Open AccessSex differences in heart mitochondria regulate diastolic dysfunction
Heart failure with preserved ejection fraction (HFpEF) exhibits a sex bias, being more common in women than men, and we hypothesize that mitochondrial sex differences might underlie this bias. As part of genet...
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Article
Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4
Amyotrophic lateral sclerosis (ALS) is a heterogenous neurodegenerative disorder that affects motor neurons and voluntary muscle control1. ALS heterogeneity includes the age of manifestation, the rate of progress...
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Article
An integrative systems genetic analysis of mammalian lipid metabolism
Dysregulation of lipid homeostasis is a precipitating event in the pathogenesis and progression of hepatosteatosis and metabolic syndrome. These conditions are highly prevalent in developed societies and curre...
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Article
Metabolic function of the CTRP family of hormones
Maintaining proper energy balance in mammals entails intimate crosstalk between various tissues and organs. These inter-organ communications are mediated, to a great extent, by secreted hormones that circulate...
