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Age- and time-dependent mitochondrial genotoxic and myopathic effects of beta-guanidinopropionic acid, a creatine analog, on rodent skeletal muscles
Beta-guanidinopropionic acid (GPA) is a creatine analog suggested as a treatment for hypertension, diabetes, and obesity, which manifest primarily in older adults. A notable side effect of GPA is the inductio...
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Open AccessParkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes
Parkin, an E3 ubiquitin ligase, plays an essential role in mitochondrial quality control. However, the mechanisms by which Parkin connects mitochondrial homeostasis with cellular metabolism in adipose tissue r...
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Open AccessSex differences in heart mitochondria regulate diastolic dysfunction
Heart failure with preserved ejection fraction (HFpEF) exhibits a sex bias, being more common in women than men, and we hypothesize that mitochondrial sex differences might underlie this bias. As part of genet...
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Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2
We have previously suggested a central role for mitochondria in the observed sex differences in metabolic traits. However, the mechanisms by which sex differences affect adipose mitochondrial function and meta...
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Reference Work Entry In depth
Pulmonary Edema
