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Article
Immune-related transcriptomic and epigenetic reconfiguration in BV2 cells after lipopolysaccharide exposure: an in vitro omics integrative study
Molecular alterations affecting microglia have been consistently associated with the inflammatory response. These cells can have pro- or anti-inflammatory activity, phenotypes thought to be regulated by epigen...
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Article
Open AccessTranscriptional dissection of symptomatic profiles across the brain of men and women with depression
Major depressive disorder (MDD) is one of the most important causes of disability worldwide. While recent work provides insights into the molecular alterations in the brain of patients with MDD, whether these ...
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Article
Regulation of impulsive and aggressive behaviours by a novel lncRNA
High impulsive and aggressive traits associate with poor behavioural self-control. Despite their importance in predicting behavioural negative outcomes including suicide, the molecular mechanisms underlying th...
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Article
Cocaine-related DNA methylation in caudate neurons alters 3D chromatin structure of the IRXA gene cluster
Epigenetic mechanisms, like those involving DNA methylation, are thought to mediate the relationship between chronic cocaine dependence and molecular changes in addiction-related neurocircuitry, but have been ...
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Article
Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex
Understanding the transcriptional changes that are engaged in stress resilience may reveal novel antidepressant targets. Here we use gene co-expression analysis of RNA-sequencing data from brains of resilient ...
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Article
Open AccessBiology and Bias in Cell Type-Specific RNAseq of Nucleus Accumbens Medium Spiny Neurons
Subcellular RNAseq promises to dissect transcriptional dynamics but is not well characterized. Furthermore, FACS may introduce bias but has not been benchmarked genome-wide. Finally, D1 and D2 dopamine recepto...
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Article
VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine
Patients with major depressive disorder (MDD) often have structural and functional deficits in the ventromedial prefrontal cortex (vmPFC), but the underlying molecular pathways are incompletely understood. The...
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Article
Open AccessGadd45b mediates depressive-like role through DNA demethylation
Animal studies using chronic social defeat stress (CSDS) in mice showed that brain-derived neurotrophic factor (BDNF) signaling in the mesolimbic dopamine (DA) circuit is important for the development of socia...
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Article
Correction: Corrigendum: Sex-specific transcriptional signatures in human depression
Nat. Med. 23, 1102–1111 (2017); published online 21 August 2017; corrected after print 7 March 2018 In the version of this article initially published, the last name of author Andrew Kasarskis was misspelled a...
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Article
Open AccessEstrogen receptor α drives pro-resilient transcription in mouse models of depression
Most people exposed to stress do not develop depression. Animal models have shown that stress resilience is an active state that requires broad transcriptional adaptations, but how this homeostatic process is ...
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Article
Social stress induces neurovascular pathology promoting depression
Studies suggest that heightened peripheral inflammation contributes to the pathogenesis of major depressive disorder. We investigated the effect of chronic social defeat stress, a mouse model of depression, on...
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Article
Sex-specific transcriptional signatures in human depression
Brain-region-specific RNA-seq from humans with major depressive disorder reveals unique transcriptomic profiles in males and females, with little overlap.
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Article
ACF chromatin-remodeling complex mediates stress-induced depressive-like behavior
Upregulation of the ATP-dependent ACF chromatin-remodeling complex in the NAc is a necessary and causal component for susceptibility to stress-induced depressive behaviors in mice, and this complex is also sho...
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Article
Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area
Comprehensive analysis of epigenetic regulation demonstrates a series of complex, interacting chromatin mechanisms by which chronic exposure to opiates downregulates Bdnf gene transcription in the ventral tegment...
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Article
β-catenin mediates stress resilience through Dicer1/microRNA regulation
β-catenin is a multi-functional protein that has an important role in the mature central nervous system; its dysfunction has been implicated in several neuropsychiatric disorders, including depression. Here we...
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Article
Loss of BDNF Signaling in D1R-Expressing NAc Neurons Enhances Morphine Reward by Reducing GABA Inhibition
The nucleus accumbens (NAc) has a central role in the mechanism of action of drugs of abuse. The major neuronal type within the NAc is the GABAergic medium spiny neuron (MSN), with two major subpopulations def...
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Article
Erratum: Epigenetic Mechanisms for the Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression in Rodents and Humans
Correction to: Neuropsychopharmacology Reviews (2012) 38, 111–123; doi:10.1038/npp.2012.149; published online 12 September 2012. In this article, there are errors in the legends of Figures 1, 2, and 3. Below a...
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Chapter
Impact of the Early-Life Environment on the Epigenome and Behavioral Development
The environment in which we live, and especially the early-life environment, regulates our behavioral development. Adversity during early life is strongly associated with problems in behavioral regulation and ...
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Article
Epigenetic Mechanisms for the Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression in Rodents and Humans
Parental care influences development across mammals. In humans such influences include effects on phenotypes, such as stress reactivity, which determine individual differences in the vulnerability for affectiv...
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Article
Astrocytic Hypertrophy in Anterior Cingulate White Matter of Depressed Suicides
Increasing evidence suggests that cortical astrocytic function is disrupted in mood disorders and suicide. The fine neuroanatomy of astrocytes, however, remains to be investigated in these psychiatric conditio...
