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Article
Blood miR-144-3p: a novel diagnostic and therapeutic tool for depression
Major depressive disorder (MDD) is the leading cause of disability worldwide. There is an urgent need for objective biomarkers to diagnose this highly heterogeneous syndrome, assign treatment, and evaluate tre...
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Article
Author Correction: Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons
A Correction to this paper has been published: https://doi.org/10.1038/s41593-021-00848-y.
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Article
Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons
Animals susceptible to chronic social defeat stress (CSDS) exhibit depression-related behaviors, with aberrant transcription across several limbic brain regions, most notably in the nucleus accumbens (NAc). Ea...
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Article
Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex
Understanding the transcriptional changes that are engaged in stress resilience may reveal novel antidepressant targets. Here we use gene co-expression analysis of RNA-sequencing data from brains of resilient ...
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Article
Open AccessGadd45b mediates depressive-like role through DNA demethylation
Animal studies using chronic social defeat stress (CSDS) in mice showed that brain-derived neurotrophic factor (BDNF) signaling in the mesolimbic dopamine (DA) circuit is important for the development of socia...
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Article
Correction: Corrigendum: Sex-specific transcriptional signatures in human depression
Nat. Med. 23, 1102–1111 (2017); published online 21 August 2017; corrected after print 7 March 2018 In the version of this article initially published, the last name of author Andrew Kasarskis was misspelled a...
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Article
Open AccessEstrogen receptor α drives pro-resilient transcription in mouse models of depression
Most people exposed to stress do not develop depression. Animal models have shown that stress resilience is an active state that requires broad transcriptional adaptations, but how this homeostatic process is ...
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Article
Sex-specific transcriptional signatures in human depression
Brain-region-specific RNA-seq from humans with major depressive disorder reveals unique transcriptomic profiles in males and females, with little overlap.
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Article
Tet1 in Nucleus Accumbens Opposes Depression- and Anxiety-Like Behaviors
Depression is a leading cause of disease burden, yet current therapies fully treat <50% of affected individuals. Increasing evidence implicates epigenetic mechanisms in depression and antidepressant action. He...
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Article
Open AccessAlterations of the Host Microbiome Affect Behavioral Responses to Cocaine
Addiction to cocaine and other psychostimulants represents a major public health crisis. The development and persistence of addictive behaviors comes from a complex interaction of genes and environment - the p...
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Article
Determining the role of microRNAs in psychiatric disorders
Accumulating studies have revealed that patients with psychiatric disorders have altered microRNA (miRNA) expression profiles in the circulation and in relevan...
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Article
Open AccessIncreased anxiety in corticotropin-releasing factor type 2 receptor-null mice requires recent acute stress exposure and is associated with dysregulated serotonergic activity in limbic brain areas
Corticotropin-releasing factor type 2 receptors (CRFR2) are suggested to facilitate successful recovery from stress to maintain mental health. They are abundant in the midbrain raphe nuclei, where they regulat...
