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    Article

    Shared and unique transcriptomic signatures of antidepressant and probiotics action in the mammalian brain

    Understanding the shared and divergent mechanisms across antidepressant (AD) classes and probiotics is critical for improving treatment for mood disorders. Here we examine the transcriptomic effects of bupropi...

    Nirmala Arul Rayan, Jonathan Aow, Michelle Gek Liang Lim in Molecular Psychiatry (2024)

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    Open Access

    Integrative multi-omics landscape of fluoxetine action across 27 brain regions reveals global increase in energy metabolism and region-specific chromatin remodelling

    Depression and anxiety are major global health burdens. Although SSRIs targeting the serotonergic system are prescribed over 200 million times annually, they have variable therapeutic efficacy and side effects...

    Nirmala Arul Rayan, Vibhor Kumar, Jonathan Aow, Naghmeh Rastegar in Molecular Psychiatry (2022)

  3. Article

    Open Access

    Genomic modules and intramodular network concordance in susceptible and resilient male mice across models of stress

    The multifactorial etiology of stress-related disorders necessitates a constant interrogation of the molecular convergences in preclinical models of stress that use disparate paradigms as stressors spanning fr...

    Salvatore G. Caradonna, Tie-Yuan Zhang, Nicholas O’Toole in Neuropsychopharmacology (2022)

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    Article

    Brain-Derived Neurotrophic Factor in the Nucleus Accumbens Mediates Individual Differences in Behavioral Responses to a Natural, Social Reward

    BDNF-oxytocin interactions in the brain are implicated in mammalian maternal behavior. We found that BDNF gene expression is increased in the hippocampus of rat mothers that show increased pup licking/grooming...

    Tie-Yuan Zhang, Dara Shahrokh, Ian C. Hellstrom, **anglan Wen in Molecular Neurobiology (2020)

  5. Article

    Open Access

    Estrogen receptor α drives pro-resilient transcription in mouse models of depression

    Most people exposed to stress do not develop depression. Animal models have shown that stress resilience is an active state that requires broad transcriptional adaptations, but how this homeostatic process is ...

    Zachary S. Lorsch, Yong-Hwee Eddie Loh, Immanuel Purushothaman in Nature Communications (2018)

  6. Article

    Open Access

    Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus

    Early life experience influences stress reactivity and mental health through effects on cognitive-emotional functions that are, in part, linked to gene expression in the dorsal and ventral hippocampus. The hip...

    Tie-Yuan Zhang, Christopher L. Keown, **anglan Wen, Junhao Li in Nature Communications (2018)

  7. Article

    Erratum: Epigenetic Mechanisms for the Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression in Rodents and Humans

    Correction to: Neuropsychopharmacology Reviews (2012) 38, 111–123; doi:10.1038/npp.2012.149; published online 12 September 2012. In this article, there are errors in the legends of Figures 1, 2, and 3. Below a...

    Tie Yuan Zhang, Benoit Labonté, **ang Lan Wen, Gustavo Turecki in Neuropsychopharmacology (2013)

  8. Article

    Epigenetic Mechanisms for the Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression in Rodents and Humans

    Parental care influences development across mammals. In humans such influences include effects on phenotypes, such as stress reactivity, which determine individual differences in the vulnerability for affectiv...

    Tie Yuan Zhang, Benoit Labonté, **ang Lan Wen, Gustavo Turecki in Neuropsychopharmacology (2013)

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    Chapter

    Epigenetics and the Environmental Regulation of Genomic Structure and Function: Implications for Health

    There are numerous examples in the behavioral sciences of the enduring effects of early experience on neural and immune function. In this article we review the emerging evidence for epigenetics as a candidate ...

    Carine I. Parent, Tie-Yuan Zhang, Michael J. Meaney in Epigenetics, Brain and Behavior (2012)

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    Article

    Impairments in water maze learning of aged rats that received dextromethorphan repeatedly during adolescent period

    Dextromethorphan (DM), an over-the-counter cough suppressant, has been recently used as a drug of abuse by teenage groups in some countries, such as the United States, Canada, and Korea. We previously showed t...

    Tie Yuan Zhang, Hee Jeong Cho, Seoul Lee, Jong-Ho Lee, Si Ho Choi in Psychopharmacology (2007)