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Article
Open AccessNeuron-specific chromosomal megadomain organization is adaptive to recent retrotransposon expansions
Regulatory mechanisms associated with repeat-rich sequences and chromosomal conformations in mature neurons remain unexplored. Here, we map cell-type specific chromatin domain organization in adult mouse cereb...
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Article
Open AccessCD200–CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma
The prevalence of asthma and airway hyperreactivity (AHR) is increasing at an alarming rate. Group 2 innate lymphoid cells (ILC2s) are copious producers of type 2 cytokines, which leads to AHR and lung inflamm...
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Article
Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex
Understanding the transcriptional changes that are engaged in stress resilience may reveal novel antidepressant targets. Here we use gene co-expression analysis of RNA-sequencing data from brains of resilient ...
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Article
Open AccessEstrogen receptor α drives pro-resilient transcription in mouse models of depression
Most people exposed to stress do not develop depression. Animal models have shown that stress resilience is an active state that requires broad transcriptional adaptations, but how this homeostatic process is ...
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Article
The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain
Schahram Akbarian and colleagues report that mutation of the gene encoding the SETDB1 (KMT1E) histone methyltransferase in mouse neurons leads to dissolution of chromosome conformations and a topologically ass...
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Protocol
Analysis and Visualization of ChIP-Seq and RNA-Seq Sequence Alignments Using ngs.plot
The continual maturation and increasing applications of next-generation sequencing technology in scientific research have yielded ever-increasing amounts of data that need to be effectively and efficiently ana...
