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Chapter
The Use of Imperfect Microsatellites for DNA Fingerprinting and Population Genetics
Since their introduction about 10 years ago, microsatellites have been demonstrated to be a powerful tool for genetic analysis of natural populations [1]. Microsatellites are easy to isolate, highly polymorphi...
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Chapter
Characterization of Gene Expression Profiles of Normal Canine Retina and Brain Using a Retinal cDNA Microarray
Microarrays have been useful in the simultaneous analysis of transcript levels of thousands of genes in different physiological states of an organism, tissue or cell (Shalon et al., 1996; Schena et al., 1996)....
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Article
Familial cutaneous lupus erythematosus (CLE) in the German shorthaired pointer maps to CFA18, a canine orthologue to human CLE
A familial form of lupus, termed exfoliative cutaneous lupus erythematosus (ECLE) has been recognized for decades in German shorthaired pointer dogs (GSP). Previous studies were suggestive of autosomal recessi...
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Chapter and Conference Paper
RPGRIP1 and Cone–Rod Dystrophy in Dogs
Cone–rod dystrophies (crd) represent a group of progressive inherited blinding diseases characterized by primary dysfunction and loss of cone photoreceptors accompanying or preceding rod death. Recessive crd type...
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Chapter and Conference Paper
Modeling the Structural Consequences of BEST1 Missense Mutations
Mutations in the bestrophin-1 gene (BEST1) are an important cause of inherited retinal disorders. Hitherto, over 100 unique allelic variants have been linked to the human BEST1 (hBEST1), and associated with disea...
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Article
Open AccessContrast sensitivity isocontours of the central visual field
Standard automated perimetry (SAP), the most common form of perimetry used in clinical practice, is associated with high test variability, impacting clinical decision making and efficiency. Contrast sensitivit...
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Article
Open AccessCustom extraction of macular ganglion cell-inner plexiform layer thickness more precisely co-localizes structural measurements with visual fields test grids
We aimed to evaluate methods of extracting optical coherence tomography (OCT)-derived macular ganglion cell-inner plexiform layer (GCIPL) thickness measurements over retinal locations corresponding to standard...
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Article
Open AccessModelling normal age-related changes in individual retinal layers using location-specific OCT analysis
Current descriptions of retinal thickness across normal age cohorts are mostly limited to global analyses, thus overlooking spatial variation across the retina and limiting spatial analyses of retinal and opti...
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Article
Open AccessEffects of stereopsis on vection, presence and cybersickness in head-mounted display (HMD) virtual reality
Stereopsis provides critical information for the spatial visual perception of object form and motion. We used virtual reality as a tool to understand the role of global stereopsis in the visual perception of s...
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Article
Open AccessThe effect of an improved ICU physical environment on outcomes and post-ICU recovery—a protocol
Intensive care medicine continues to improve, with advances in technology and care provision leading to improved patient survival. However, this has not been matched by similar advances in ICU bedspace design....
