35 Result(s)
within
Christian Schlötterer
-
Article
Open AccessReproductive isolation arises during laboratory adaptation to a novel hot environment
Reproductive isolation can result from adaptive processes (e.g., ecological speciation and mutation-order speciation) or stochastic processes such as “system drift” model. Ecological speciation predicts barrie...
-
Article
Open AccessNatural variation in Drosophila shows weak pleiotropic effects
Pleiotropy describes the phenomenon in which a gene affects multiple phenotypes. The extent of pleiotropy is still disputed, mainly because of issues of inadequate power of analyses. A further challenge is tha...
-
Article
Open AccessThe genetic architecture of temperature adaptation is shaped by population ancestry and not by selection regime
Understanding the genetic architecture of temperature adaptation is key for characterizing and predicting the effect of climate change on natural populations. One particularly promising approach is Evolve and ...
-
Article
Author Correction: Polygenic adaptation: a unifying framework to understand positive selection
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Polygenic adaptation: a unifying framework to understand positive selection
Most adaption processes have a polygenic genetic basis, but even with the recent explosive growth of genomic data we are still lacking a unified framework describing the dynamics of selected alleles. Building ...
-
Article
Open AccessFitness effects for Ace insecticide resistance mutations are determined by ambient temperature
Insect pest control programs often use periods of insecticide treatment with intermittent breaks, to prevent fixing of mutations conferring insecticide resistance. Such mutations are typically costly in an ins...
-
Article
Open AccessBenchmarking software tools for detecting and quantifying selection in evolve and resequencing studies
The combination of experimental evolution with whole-genome resequencing of pooled individuals, also called evolve and resequence (E&R) is a powerful approach to study the selection processes and to infer the ...
-
Article
Open AccessThe horse Y chromosome as an informative marker for tracing sire lines
Analysis of the Y chromosome is the best-established way to reconstruct paternal family history in humans. Here, we applied fine-scaled Y-chromosomal haploty** in horses with biallelic markers and demonstrat...
-
Article
Open AccessA simple genetic basis of adaptation to a novel thermal environment results in complex metabolic rewiring in Drosophila
Population genetic theory predicts that rapid adaptation is largely driven by complex traits encoded by many loci of small effect. Because large-effect loci are quickly fixed in natural populations, they shoul...
-
Article
Open AccessHigh-throughput fecundity measurements in Drosophila
Fecundity is probably the most frequently studied fitness component in Drosophila. Nevertheless, currently used methods to measure fecundity are not well-suited for large-scale experiments, with many populations ...
-
Article
Contesting the evidence for non-adaptive plasticity
-
Article
Open AccessStrong epistatic and additive effects of linked candidate SNPs for Drosophila pigmentation have implications for analysis of genome-wide association studies results
The map** resolution of genome-wide association studies (GWAS) is limited by historic recombination events and effects are often assigned to haplotype blocks rather than individual SNPs. It is not clear how ...
-
Article
Open AccessSequencing of the genus Arabidopsis identifies a complex history of nonbifurcating speciation and abundant trans-specific polymorphism
Magnus Nordborg and colleagues report a genomic analysis of all 27 known species in the genus Arabidopsis. They find evidence for a complex speciation history that is not accurately reflected by a traditional bif...
-
Article
Sequencing pools of individuals — mining genome-wide polymorphism data without big funding
Whole-genome sequencing of pools of individuals (Pool-seq) is a cost-effective approach to determine genome-wide allele frequencies in an unbiased manner from ...
-
Article
Open AccessCombining evidence of selection with association analysis increases power to detect regions influencing complex traits in dairy cattle
Hitchhiking map** and association studies are two popular approaches to map genotypes to phenotypes. In this study we combine both approaches to complement their specific strengths and weaknesses, resulting ...
-
Article
Open AccessCANGS DB: a stand-alone web-based database tool for processing, managing and analyzing 454 data in biodiversity studies
Next generation sequencing (NGS) is widely used in metagenomic and transcriptomic analyses in biodiversity. The ease of data generation provided by NGS platforms has allowed researchers to perform these analys...
-
Article
Open AccessPoPoolation DB: a user-friendly web-based database for the retrieval of natural polymorphisms in Drosophila
The enormous potential of natural variation for the functional characterization of genes has been neglected for a long time. Only since recently, functional geneticists are starting to account for natural vari...
-
Article
Open AccessNon-random genomic integration - an intrinsic property of retrogenes in Drosophila?
The Drosophila X-chromosome shows a significant underrepresentation of genes with male-biased gene expression (demasculinization). This trend is matched by retrogenes, which typically have a male biased gene e...
-
Article
Open AccessCANGS: a user-friendly utility for processing and analyzing 454 GS-FLX data in biodiversity studies
Next generation sequencing (NGS) technologies have substantially increased the sequence output while the costs were dramatically reduced. In addition to the use in whole genome sequencing, the 454 GS-FLX platf...
-
Article
Open AccessPanGEA: Identification of allele specific gene expression using the 454 technology
Next generation sequencing technologies hold great potential for many biological questions. While mainly used for genomic sequencing, they are also very promising for gene expression profiling. Sequencing of c...
