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  1. Article

    Open Access

    The association between conjunctival and scleral thickness and ocular surface ultraviolet autofluorescence

    Ultraviolet autofluorescence (UVAF) imaging is used to visualise ocular surface changes due to sunlight exposure and so is considered to be a biomarker for UV damage. The conjunctival and scleral thicknesses o...

    Pryntha Rajasingam, Alyra Shaw, Brett Davis, David Alonso-Caneiro in Scientific Reports (2023)

  2. Article

    Open Access

    Diurnal changes in choroidal optical coherence tomography angiography indices over 24 hours in healthy young adults

    This prospective study investigated the magnitude and pattern of variation in choroidal optical coherence tomography angiography (OCT-A) indices every 4 h over 24 h in healthy young myopic (n = 24) and non-myo...

    Barsha Lal, David Alonso-Caneiro, Scott A. Read, Andrew Carkeet in Scientific Reports (2023)

  3. Article

    Open Access

    A comparison of deep learning U-Net architectures for posterior segment OCT retinal layer segmentation

    Deep learning methods have enabled a fast, accurate and automated approach for retinal layer segmentation in posterior segment OCT images. Due to the success of semantic segmentation methods adopting the U-Net...

    Jason Kugelman, Joseph Allman, Scott A. Read, Stephen J. Vincent in Scientific Reports (2022)

  4. Article

    Open Access

    Evaluation of focus and deep learning methods for automated image grading and factors influencing image quality in adaptive optics ophthalmoscopy

    Adaptive optics flood illumination ophthalmoscopy (AO-FIO) is an established imaging tool in the investigation of retinal diseases. However, the clinical interpretation of AO-FIO images can be challenging due ...

    Danuta M. Sampson, David Alonso-Caneiro, Avenell L. Chew, Jonathan La in Scientific Reports (2021)

  5. Article

    Open Access

    A deep learning method for automatic segmentation of the bony orbit in MRI and CT images

    This paper proposes a fully automatic method to segment the inner boundary of the bony orbit in two different image modalities: magnetic resonance imaging (MRI) and computed tomography (CT). The method, based ...

    Jared Hamwood, Beat Schmutz, Michael J. Collins, Mark C. Allenby in Scientific Reports (2021)

  6. No Access

    Article

    Data augmentation for patch-based OCT chorio-retinal segmentation using generative adversarial networks

    Many clinical and research tasks rely critically upon the segmentation of tissue layers in optical coherence tomography (OCT) images of the posterior eye (the retina and choroid). However, a major limitation o...

    Jason Kugelman, David Alonso-Caneiro, Scott A. Read in Neural Computing and Applications (2021)

  7. Article

    Open Access

    Associations between seven-year C-reactive protein trajectory or pack-years smoked with choroidal or retinal thicknesses in young adults

    Inflammation and cigarette smoking predispose to macular diseases, and choroidal and retinal thinning. We explored the choroidal and retinal thicknesses in young adults against their 7-year C-reactive protein ...

    Samantha Sze-Yee Lee, Darren John Beales, Fred K. Chen, Seyhan Yazar in Scientific Reports (2021)

  8. Article

    Open Access

    Custom extraction of macular ganglion cell-inner plexiform layer thickness more precisely co-localizes structural measurements with visual fields test grids

    We aimed to evaluate methods of extracting optical coherence tomography (OCT)-derived macular ganglion cell-inner plexiform layer (GCIPL) thickness measurements over retinal locations corresponding to standard...

    Janelle Tong, David Alonso-Caneiro, Nayuta Yoshioka in Scientific Reports (2020)

  9. Article

    Open Access

    Automatic choroidal segmentation in OCT images using supervised deep learning methods

    The analysis of the choroid in the eye is crucial for our understanding of a range of ocular diseases and physiological processes. Optical coherence tomography (OCT) imaging provides the ability to capture hig...

    Jason Kugelman, David Alonso-Caneiro, Scott A. Read, Jared Hamwood in Scientific Reports (2019)

  10. Article

    Open Access

    Wide-field choroidal thickness in myopes and emmetropes

    There is a paucity of knowledge regarding the normal in-vivo thickness of the choroid beyond the macula (~17°). In this study, the choroidal thickness of 27 healthy young adults was examined across the macular (t...

    Hosein Hoseini-Yazdi, Stephen J. Vincent, Michael J. Collins in Scientific Reports (2019)

  11. No Access

    Chapter and Conference Paper

    Automatic Retinal and Choroidal Boundary Segmentation in OCT Images Using Patch-Based Supervised Machine Learning Methods

    The assessment of retinal and choroidal thickness derived from spec...

    David Alonso-Caneiro, Jason Kugelman in Computer Vision – ACCV 2018 Workshops (2019)

  12. Article

    Open Access

    Daily morning light therapy is associated with an increase in choroidal thickness in healthy young adults

    Ambient light exposure is one environmental factor thought to play a role in the regulation of eye growth and refractive error development, and choroidal thickness changes have also been linked to longer term ...

    Scott A. Read, Emily C. Pieterse, David Alonso-Caneiro in Scientific Reports (2018)

  13. Article

    Open Access

    Anterior eye tissue morphology: Scleral and conjunctival thickness in children and young adults

    The sclera and conjunctiva form part of the eye’s tough, protective outer coat, and play important roles in the eye’s mechanical protection and immune defence, as well as in determining the size and shape of t...

    Scott A. Read, David Alonso-Caneiro, Stephen J. Vincent in Scientific Reports (2016)