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Article
Transcriptional and epigenetic regulation of macrophages in atherosclerosis
Monocytes and macrophages provide defence against pathogens and danger signals. These cells respond to stimulation in a fast and stimulus-specific manner by utilizing complex cascaded activation by lineage-det...
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Article
Open AccessExtensive epigenomic integration of the glucocorticoid response in primary human monocytes and in vitro derived macrophages
Glucocorticoid receptor is a transcription factor that is ubiquitously expressed. Glucocorticoids are circadian steroids that regulate a wide range of bodily functions, including immunity. Here we report that ...
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Article
Open AccessThe evolutionary and phylogeographic history of woolly mammoths: a comprehensive mitogenomic analysis
Near the end of the Pleistocene epoch, populations of the woolly mammoth (Mammuthus primigenius) were distributed across parts of three continents, from western Europe and northern Asia through Beringia to the At...
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Chapter and Conference Paper
A System for Hypertension Management Assistance Based on the Technologies of the Smart Spaces
Affecting up to 40% of the world’s population, arterial hypertension results in high economic and social burden. Long-term treatment period along with the necessity of personal lifestyle changes lead to the lo...
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Article
Open AccessGlucocorticoid receptor and nuclear factor kappa-b affect three-dimensional chromatin organization
The impact of signal-dependent transcription factors, such as glucocorticoid receptor and nuclear factor kappa-b, on the three-dimensional organization of chromatin remains a topic of discussion. The possible ...
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Chapter and Conference Paper
RPGRIP1 and Cone–Rod Dystrophy in Dogs
Cone–rod dystrophies (crd) represent a group of progressive inherited blinding diseases characterized by primary dysfunction and loss of cone photoreceptors accompanying or preceding rod death. Recessive crd type...
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Article
Species-specific responses of Late Quaternary megafauna to climate and humans
Despite decades of research, the roles of climate and humans in driving the dramatic extinctions of large-bodied mammals during the Late Quaternary period remain contentious. Here we use ancient DNA, species d...
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Article
Discovery of lost diversity of paternal horse lineages using ancient DNA
Modern domestic horses display abundant genetic diversity within female-inherited mitochondrial DNA, but practically no sequence diversity on the male-inherited Y chromosome. Several hypotheses have been propo...
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Article
Modelling excess surface energy in dry and wetted calcite systems
We have combined the calcite force field of Hwang et al. (J. Phys. Chem. B 105:4,122–4,127, 2001) with the F3C water model and a hybrid Lennard-Jones/van der Waals 3-site potential for CO2 to investigate the ...
