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Article
Open AccessJAK-STAT signaling maintains homeostasis in T cells and macrophages
Immune cells need to sustain a state of constant alertness over a lifetime. Yet, little is known about the regulatory processes that control the fluent and fragile balance that is called homeostasis. Here we d...
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Article
Open AccessImmortalized murine tenocyte cells: a novel and innovative tool for tendon research
Primary tenocytes rapidly undergo senescence and a phenotypic drift upon in vitro monolayer culture, which limits tendon research. The Ink4a/Arf locus encodes the proteins p16Ink4a/Arf and p14ARF (p19ARF in mice)...
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Article
Open AccessSelective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains
The transcription factor STAT3 is frequently activated in human solid and hematological malignancies and remains a challenging therapeutic target with no approved drugs to date. Here, we develop synthetic anti...
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Article
Open AccessSTAT5BN642H drives transformation of NKT cells: a novel mouse model for CD56+ T-LGL leukemia
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Article
Open AccessRetraction Note: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessTwins with different personalities: STAT5B—but not STAT5A—has a key role in BCR/ABL-induced leukemia
Deregulation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway is found in cancer with STAT5A/B controlling leukemic cell survival and disease progression. As ...
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Open AccessCorrection: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation
Since publication of the article, the authors became aware that Figure 6(A,D) contained errors in the bands and loading controls. The newly compiled Figure 6A and 6D is given below.
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Article
Open AccessPharmacologic inhibition of STAT5 in acute myeloid leukemia
The transcription factor STAT5 is an essential downstream mediator of many tyrosine kinases (TKs), particularly in hematopoietic cancers. STAT5 is activated by FLT3-ITD, which is a constitutively active TK dri...
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Article
It is a differentiation game: STAT5 in a new role
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Open AccessRETRACTED ARTICLE: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation
Ewing sarcoma (ES) is the second most frequent childhood bone cancer driven by the EWS/FLI1 (EF) fusion protein. Genetically defined ES models are needed to understand how EF expression changes bone precursor ...