11 Result(s)

Article

JAK-STAT signaling maintains homeostasis in T cells and macrophages

Immune cells need to sustain a state of constant alertness over a lifetime. Yet, little is known about the regulatory processes that control the fluent and fragile balance that is called homeostasis. Here we d...

Nikolaus Fortelny, Matthias Farlik, Victoria Fife, Anna-Dorothea Gorki… in Nature Immunology (2024)

Article

Immortalized murine tenocyte cells: a novel and innovative tool for tendon research

Primary tenocytes rapidly undergo senescence and a phenotypic drift upon in vitro monolayer culture, which limits tendon research. The Ink4a/Arf locus encodes the proteins p16^Ink4a/Arf and p14^ARF (p19^ARF in mice)...

Gil Lola Oreff, Barbara Maurer, Ahmed N. ELKhamary, Iris Gerner… in Scientific Reports (2023)

Article

Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains

The transcription factor STAT3 is frequently activated in human solid and hematological malignancies and remains a challenging therapeutic target with no approved drugs to date. Here, we develop synthetic anti...

Grégory La Sala, Camille Michiels, Tim Kükenshöner… in Nature Communications (2020)

Article

STAT5B^N642H drives transformation of NKT cells: a novel mouse model for CD56⁺ T-LGL leukemia

Klara Klein, Agnieszka Witalisz-Siepracka, Barbara Maurer, Daniela Prinz… in Leukemia (2019)

Article

Retraction Note: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Tahereh Javaheri, Zahra Kazemi, Jan Pencik, Ha T. T. Pham… in Cell Death & Disease (2019)

Article

Twins with different personalities: STAT5B—but not STAT5A—has a key role in BCR/ABL-induced leukemia

Deregulation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway is found in cancer with STAT5A/B controlling leukemic cell survival and disease progression. As ...

Sebastian Kollmann, Eva Grundschober, Barbara Maurer, Wolfgang Warsch… in Leukemia (2019)

Article

Correction: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation

Since publication of the article, the authors became aware that Figure 6(A,D) contained errors in the bands and loading controls. The newly compiled Figure 6A and 6D is given below.

Tahereh Javaheri, Zahra Kazemi, Jan Pencik, Ha T. T. Pham… in Cell Death & Disease (2018)

Article

Pharmacologic inhibition of STAT5 in acute myeloid leukemia

The transcription factor STAT5 is an essential downstream mediator of many tyrosine kinases (TKs), particularly in hematopoietic cancers. STAT5 is activated by FLT3-ITD, which is a constitutively active TK dri...

Bettina Wingelhofer, Barbara Maurer, Elizabeth C. Heyes, Abbarna A. Cumaraswamy… in Leukemia (2018)

Article

It is a differentiation game: STAT5 in a new role

Barbara Maurer, Matthias Farlik, Veronika Sexl in Cell Death & Differentiation (2017)

Article

RETRACTED ARTICLE: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation

Ewing sarcoma (ES) is the second most frequent childhood bone cancer driven by the EWS/FLI1 (EF) fusion protein. Genetically defined ES models are needed to understand how EF expression changes bone precursor ...

Tahereh Javaheri, Zahra Kazemi, Jan Pencik, Ha TT Pham… in Cell Death & Disease (2016)