3 Result(s)

Article

A kinase-independent role for CDK8 in BCR-ABL1⁺ leukemia

Cyclin-dependent kinases (CDKs) are frequently deregulated in cancer and represent promising drug targets. We provide evidence that CDK8 has a key role in B-ALL. Loss of CDK8 in leukemia mouse models significa...

Ingeborg Menzl, Tinghu Zhang, Angelika Berger-Becvar… in Nature Communications (2019)

Article

Twins with different personalities: STAT5B—but not STAT5A—has a key role in BCR/ABL-induced leukemia

Deregulation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway is found in cancer with STAT5A/B controlling leukemic cell survival and disease progression. As ...

Sebastian Kollmann, Eva Grundschober, Barbara Maurer, Wolfgang Warsch… in Leukemia (2019)

Article

The transcription factor STAT5 drives mutation and imatinib resistance in chronic myeloid leukemia via ROS production

Eva Grundschober, Wolfgang Warsch, Veronika Sexl in BMC Pharmacology (2011)